PKD2 polycystin 2, transient receptor potential cation channel [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: PKD2provided by VGNC
Official Full Name: polycystin 2, transient receptor potential cation channelprovided by VGNC
Primary source: VGNC:VGNC:7424
Locus tag: CK820_G0022094
See related: Ensembl:ENSPTRG00000016267
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	3	NC_072401.2 (89375831..89445937)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	4	NC_072402.1 (89375811..89445910)

Chromosome 3 - NC_072401.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

SHGC-67606 (e-PCR)
- UniSTS:46393

PKD2_477 (e-PCR)
- UniSTS:280910

SHGC-24101 (e-PCR)
- UniSTS:9043

SHGC-8591 (e-PCR)
- UniSTS:27987

D4S2796 (e-PCR)
- UniSTS:24407

SHGC-67224 (e-PCR)
- UniSTS:77401

G59384 (e-PCR)
- UniSTS:136549

SHGC-148257 (e-PCR)
- UniSTS:176285

SHGC-50276 (e-PCR)
- UniSTS:56245

G63630 (e-PCR)
- UniSTS:140741

SHGC-111600 (e-PCR)
- UniSTS:168425

STS-R48232 (e-PCR)
- UniSTS:12782

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables muscle alpha-actinin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables potassium channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables voltage-gated sodium channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in detection of mechanical stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: polycystin-2

Names: polycystic kidney disease 2 (autosomal dominant)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072401.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

89375831..89445937

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016951850.4 → XP_016807339.1 polycystin-2

UniProtKB/TrEMBL

A0A2J8MA81, A0A6D2VSE2, H2QPV4, K7B7C7

Related

ENSPTRP00000027941.5

Conserved Domains (3) summary

pfam08016
Location:267 → 687

PKD_channel; Polycystin cation channel

cd15902
Location:754 → 782

EFh_HEF; EF-hand motif [structural motif]

cl23634
Location:724 → 792

EFh_HEF; EF-hand, calcium binding motif, found in the hexa-EF hand proteins family