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Pfdn2 Prefoldin 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46121, updated on 18-Sep-2024

Summary

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Official Symbol
Pfdn2provided by FlyBase
Official Full Name
Prefoldin 2provided by FlyBase
Primary source
FLYBASE:FBgn0010741
Locus tag
Dmel_CG6302
See related
AllianceGenome:FB:FBgn0010741
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6302; Dmel\CG6302; l(3)01239; l(3)j9B4; P01239; pfdn2
Summary
Predicted to enable protein folding chaperone. Involved in establishment or maintenance of neuroblast polarity. Part of prefoldin complex. Is expressed in embryonic/larval brain; ganglion mother cell; larval neuroblast; secondary neuroblast; and spermatozoon. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to several human genes including PFDN2 (prefoldin subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Pfdn2 in Genome Data Viewer
Location:
68A4-68A4; 3-34 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11073292..11074388, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11066392..11067488, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Suppressor of Under-Replication Neighboring gene uncharacterized protein Neighboring gene Molybdenum cofactor synthesis 1 Neighboring gene Nucleolar complex protein 1 Neighboring gene JIL-1 kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages. Zhang W, et al. Genetics, 2003 Nov. PMID 14668387, Free PMC Article
  2. Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation. Zhang Y, et al. Sci Rep, 2016 Mar 30. PMID 27025979, Free PMC Article
  3. The Drosophila suppressor of underreplication protein binds to late-replicating regions of polytene chromosomes. Makunin IV, et al. Genetics, 2002 Mar. PMID 11901119, Free PMC Article
  4. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
  5. Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration. Muraro NI, et al. J Neurobiol, 2006 Oct. PMID 16967506

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prefoldin acts synergistically with Pins to regulate asymmetric division of both neuroblasts and Intermediate Neural Progenitors.
    Title: Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in establishment or maintenance of neuroblast polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of prefoldin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of prefoldin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prefoldin 2
Names
CG6302-PA
CG6302-PB
Pfdn2-PA
Pfdn2-PB
lethal (3) 01239
prefoldin beta-like subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11073292..11074388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274767.1 → NP_001261696.1  prefoldin 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261696.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C6SV13, Q9VTE5
    UniProtKB/TrEMBL
    M9PF40
    Conserved Domains (1) summary
    pfam01920
    Location:13 → 115
    Prefoldin_2; Prefoldin subunit

  2. NM_168438.2 → NP_729659.1  prefoldin 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729659.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C6SV13, Q9VTE5
    UniProtKB/TrEMBL
    M9PF40
    Related
    FBpp0075967
    Conserved Domains (1) summary
    pfam01920
    Location:13 → 115
    Prefoldin_2; Prefoldin subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PF40 M9PF40
Q9VTE5.1 Q9VTE5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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