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NAT1 NAT1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46020, updated on 2-Nov-2024

Summary

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Official Symbol
NAT1provided by FlyBase
Official Full Name
NAT1provided by FlyBase
Primary source
FLYBASE:FBgn0010488
Locus tag
Dmel_CG3845
See related
AllianceGenome:FB:FBgn0010488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3845; Dmel\CG3845; dNAT1; l(2)01424; Nat1
Summary
Predicted to enable mRNA binding activity and translation initiation factor activity. Involved in chaeta development. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including adult central complex; adult head; brain; embryonic/larval salivary gland; and imaginal disc. Orthologous to human EIF4G2 (eukaryotic translation initiation factor 4 gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See NAT1 in Genome Data Viewer
Location:
49E1-49E1; 2-67 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12915994..12923734)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8803499..8811239)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46336 Neighboring gene long non-coding RNA:CR46337 Neighboring gene long non-coding RNA:CR44461 Neighboring gene uncharacterized protein Neighboring gene sugarbabe Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cellular mechanisms governing synaptic development in Drosophila melanogaster. Keshishian H, et al. J Neurobiol, 1993 Jun. PMID 8251016
  2. Drosophila NAT1, a homolog of the vertebrate translational regulator NAT1/DAP5/p97, is required for embryonic germband extension and metamorphosis. Yoshikane N, et al. Dev Growth Differ, 2007 Sep. PMID 17716306
  3. RNA-binding protein Nocte regulates Drosophila development by promoting translation reinitiation on mRNAs with long upstream open reading frames. Zhang T, et al. Nucleic Acids Res, 2024 Jan 25. PMID 38000373, Free PMC Article
  4. Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2). Takahashi K, et al. Genomics, 2005 Mar. PMID 15718103
  5. Dissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGG repeat-associated toxicity in a Drosophila model of FXTAS. Malik I, et al. Neurobiol Dis, 2023 Aug. PMID 37352983, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chaeta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NAT1
Names
CG3845-PA
CG3845-PB
CG3845-PD
NAT1-PA
NAT1-PB
NAT1-PD
lethal (2) 01424
NP_001033943.2
  • non-AUG (AUU) translation initiation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12915994..12923734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165961.2 → NP_725242.1  NAT1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725242.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E996, Q86NR8
    Related
    FBpp0086899
    Conserved Domains (4) summary
    cd11559
    Location:744 → 890
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    smart00544
    Location:558 → 671
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02854
    Location:1 → 173
    MIF4G; MIF4G domain
    pfam15320
    Location:247 → 295
    RAM; mRNA cap methylation, RNMT-activating mini protein

  2. NM_001038854.2 → NP_001033943.2  NAT1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033943.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z968, Q5KTT4
    Conserved Domains (4) summary
    cd11559
    Location:1314 → 1460
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    smart00544
    Location:1128 → 1241
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02854
    Location:518 → 743
    MIF4G; MIF4G domain
    pfam15320
    Location:817 → 865
    RAM; mRNA cap methylation, RNMT-activating mini protein

  3. NM_143770.3 → NP_652027.2  NAT1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652027.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E996, Q86NR8
    Related
    FBpp0086900
    Conserved Domains (4) summary
    cd11559
    Location:744 → 890
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    smart00544
    Location:558 → 671
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02854
    Location:1 → 173
    MIF4G; MIF4G domain
    pfam15320
    Location:247 → 295
    RAM; mRNA cap methylation, RNMT-activating mini protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z968 A1Z968
Q0E996 Q0E996

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