Ldh Lactate dehydrogenase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ldhprovided by FlyBase
Official Full Name: Lactate dehydrogenaseprovided by FlyBase
Primary source: FLYBASE:FBgn0001258
Locus tag: Dmel_CG10160
See related: AllianceGenome:FB:FBgn0001258
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10160; dLdh; dLDH; dLdha; Dmel\CG10160; dmLDH; Imp-L3; IMP-L3; Impl 3; impl3; impL3; Impl3; ImpL3; IMPL3; Ld; ldh; LDH; lincRNA.S4223
Summary: Enables L-lactate dehydrogenase activity and alpha-ketoglutarate reductase activity. Involved in NADH metabolic process; lactate catabolic process; and pyruvate metabolic process. Located in cytoplasm. Is expressed in several structures, including adult heart; imaginal disc; mesoderm; muscle cell; and organism subdivision. Used to study disease of metabolism. Orthologous to several human genes including LDHA (lactate dehydrogenase A); LDHAL6A (lactate dehydrogenase A like 6A); and LDHB (lactate dehydrogenase B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 65A11-65A11; 3-16 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6259105..6262694, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6252205..6255794, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of genetic and molecular tools for studying the endogenous expression of Lactate dehydrogenase in Drosophila melanogaster.
Title: Characterization of genetic and molecular tools for studying the endogenous expression of Lactate dehydrogenase in Drosophila melanogaster.
eIF4EHP promotes Ldh mRNA translation in and fruit fly adaptation to hypoxia.
Title: eIF4EHP promotes Ldh mRNA translation in and fruit fly adaptation to hypoxia.
Lactate dehydrogenase expression modulates longevity and neurodegeneration in Drosophila melanogaster.
Title: Lactate dehydrogenase expression modulates longevity and neurodegeneration in Drosophila melanogaster.
Drosophila melanogaster larvae lacking both LDH and G3P dehydrogenase (GPDH1) exhibit growth defects, synthetic lethality and decreased glycolytic flux.
Title: Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism during Drosophila melanogaster larval development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables L-lactate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-lactate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-lactate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables alpha-ketoglutarate reductase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in NADH metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lactate biosynthetic process from pyruvate	IDA Inferred from Direct Assay more info	PubMed
involved_in lactate biosynthetic process from pyruvate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lactate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lactate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyruvate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyruvate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyruvate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lactate dehydrogenase

Names: CG10160-PA; CG10160-PB; CG10160-PC; CG10160-PD; Ecdysone-induced gene L3; Ecdysone-inducible gene L3; Ldh-PA; Ldh-PB; Ldh-PC; Ldh-PD; lactate dehydrogenase B; lactate/malate dehydrogenease; lactic DH

NP_001261474.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.27

NP_001261475.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.27

NP_001261476.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.27

NP_476581.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.27

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

6259105..6262694 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274545.2 → NP_001261474.1 lactate dehydrogenase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261474.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95028, Q9VRW6

UniProtKB/TrEMBL

B5RJQ0, Q32KE6

Conserved Domains (1) summary

cd05293
Location:18 → 329

LDH_1; A subgroup of L-lactate dehydrogenases
NM_057233.5 → NP_476581.1 lactate dehydrogenase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476581.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95028, Q9VRW6

UniProtKB/TrEMBL

B5RJQ0, Q32KE6

Related

FBpp0076716

Conserved Domains (1) summary

cd05293
Location:18 → 329

LDH_1; A subgroup of L-lactate dehydrogenases
NM_001274547.1 → NP_001261476.1 lactate dehydrogenase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261476.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95028, Q9VRW6

UniProtKB/TrEMBL

B5RJQ0, Q32KE6

Conserved Domains (1) summary

cd05293
Location:18 → 329

LDH_1; A subgroup of L-lactate dehydrogenases
NM_001274546.1 → NP_001261475.1 lactate dehydrogenase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261475.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95028, Q9VRW6

UniProtKB/TrEMBL

B5RJQ0, Q32KE6

Conserved Domains (1) summary

cd05293
Location:18 → 329

LDH_1; A subgroup of L-lactate dehydrogenases