UHRF1 ubiquitin like with PHD and ring finger domains 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: UHRF1provided by VGNC
Official Full Name: ubiquitin like with PHD and ring finger domains 1provided by VGNC
Primary source: VGNC:VGNC:8300
Locus tag: CK820_G0045057
See related: Ensembl:ENSPTRG00000010326
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	20	NC_072418.2 (7254757..7307917)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	19	NC_072417.1 (7254804..7307959)

Chromosome 20 - NC_072418.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH26361 (e-PCR)
- UniSTS:90369

D11S3374 (e-PCR)
- UniSTS:152616

RH36905 (e-PCR)
- UniSTS:87932

D19S216 (e-PCR), detects polymorphism
- UniSTS:51853

G22294 (e-PCR)
- UniSTS:67554

D5S1597E (e-PCR)
- UniSTS:151019

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of gene expression via chromosomal CpG island methylation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase UHRF1

Names: ubiquitin-like, containing PHD and RING finger domains, 1

XP_001139745.1

EC 6.3.2.19

XP_001139916.3

EC 6.3.2.19

XP_016790233.3

EC 6.3.2.19

XP_016790234.1

EC 6.3.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072418.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

7254757..7307917

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001139916.7 → XP_001139916.3 E3 ubiquitin-protein ligase UHRF1 isoform X1
XM_016934744.4 → XP_016790233.3 E3 ubiquitin-protein ligase UHRF1 isoform X2
XM_001139745.6 → XP_001139745.1 E3 ubiquitin-protein ligase UHRF1 isoform X3

UniProtKB/TrEMBL

A0A2J8JR81, A0A2J8JR84, A0A803KHL2, K7CBV7

Conserved Domains (6) summary

cd01797
Location:1 → 78

NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF

COG5152
Location:613 → 783

COG5152; Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only]

cd15616
Location:317 → 363

PHD_UHRF1; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 1 (UHRF1)

pfam02182
Location:417 → 584

SAD_SRA; SAD/SRA domain

pfam12148
Location:134 → 284

TTD; Tandem tudor domain within UHRF1

cd16613
Location:721 → 766

RING-HC_UHRF; RING finger, HC subclass, found in ubiquitin-like PHD and RING finger domain-containing proteins, UHRF1 and UHRF2, and similar proteins
XM_016934745.4 → XP_016790234.1 E3 ubiquitin-protein ligase UHRF1 isoform X4

UniProtKB/TrEMBL

A0A2J8JR81, A0A803KHL2, K7CBV7