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NEDD4L NEDD4 like E3 ubiquitin protein ligase [ Pan troglodytes (chimpanzee) ]

Gene ID: 455443, updated on 10-Oct-2024

Summary

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Official Symbol
NEDD4Lprovided by VGNC
Official Full Name
NEDD4 like E3 ubiquitin protein ligaseprovided by VGNC
Primary source
VGNC:VGNC:84274
Locus tag
CK820_G0011383
See related
Ensembl:ENSPTRG00000010051
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See NEDD4L in Genome Data Viewer
Location:
chromosome: 17
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 17 NC_072415.2 (68103783..68467395)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 18 NC_072416.1 (67039457..67403099)

Chromosome 17 - NC_072415.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107969408 Neighboring gene uncharacterized LOC134808640 Neighboring gene hypothetical protein Neighboring gene uncharacterized LOC129137818 Neighboring gene uncharacterized LOC129137825 Neighboring gene microRNA mir-122 Neighboring gene alpha kinase 2 Neighboring gene uncharacterized LOC107969506

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sodium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase NEDD4-like
Names
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
XP_001140979.1
XP_001141065.1
XP_009432341.1
XP_009432343.1
XP_009432347.1
XP_016789284.1
XP_016789287.1
XP_054527650.1
XP_054527651.1
XP_054527652.1
XP_054527653.1
XP_054527654.1
XP_054527655.1
XP_054527656.1
XP_054527657.1
XP_054527659.1
XP_054527660.1
XP_063651817.1
XP_063651818.1
XP_063651819.1
XP_063651821.1
XP_063651822.1
XP_063651824.1
XP_063651825.1
XP_063651826.1
XP_063651827.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072415.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    68103783..68467395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001140979.7 → XP_001140979.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

    See identical proteins and their annotated locations for XP_001140979.1

    UniProtKB/TrEMBL
    A0A2J8NDK9, A0A2J8NDL2, A0A663DG91, H2RCB1
    Related
    ENSPTRP00000057037.2
    Conserved Domains (5) summary
    cd04033
    Location:21 → 153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:549 → 581
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:642 → 971
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03247
    Location:319 → 502
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:387 → 416
    WW; WW domain

  2. XM_063795757.1 → XP_063651827.1  E3 ubiquitin-protein ligase NEDD4-like isoform X22

  3. XM_001141065.7 → XP_001141065.1  E3 ubiquitin-protein ligase NEDD4-like isoform X18

    See identical proteins and their annotated locations for XP_001141065.1

    UniProtKB/TrEMBL
    A0A2J8NDL2, A0A2J8NDL4, A0A663D9Y8, K7BRG0
    Related
    ENSPTRP00000066882.1
    Conserved Domains (4) summary
    cd04033
    Location:21 → 153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:529 → 561
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:622 → 951
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:367 → 396
    WW; WW domain

  4. XM_063795749.1 → XP_063651819.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

    UniProtKB/TrEMBL
    A0A2I3RXL8

  5. XM_063795752.1 → XP_063651822.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

    UniProtKB/TrEMBL
    A0A2J8NDM3

  6. XM_063795747.1 → XP_063651817.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

  7. XM_054671682.1 → XP_054527657.1  E3 ubiquitin-protein ligase NEDD4-like isoform X13

  8. XM_063795748.1 → XP_063651818.1  E3 ubiquitin-protein ligase NEDD4-like isoform X14

  9. XM_054671685.2 → XP_054527660.1  E3 ubiquitin-protein ligase NEDD4-like isoform X19

  10. XM_054671684.1 → XP_054527659.1  E3 ubiquitin-protein ligase NEDD4-like isoform X15

  11. XM_009434072.5 → XP_009432347.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

    See identical proteins and their annotated locations for XP_009432347.1

    UniProtKB/TrEMBL
    A0A2J8NDL1, A0A2J8NDL2
    Conserved Domains (5) summary
    smart00456
    Location:428 → 460
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:521 → 850
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03247
    Location:198 → 381
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:266 → 295
    WW; WW domain
    cl14603
    Location:1 → 32
    C2; C2 domain

  12. XM_063795754.1 → XP_063651824.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

    UniProtKB/TrEMBL
    A0A2J8NDM3

  13. XM_063795751.1 → XP_063651821.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

    UniProtKB/TrEMBL
    A0A2J8NDL1

  14. XM_063795755.1 → XP_063651825.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

    UniProtKB/TrEMBL
    A0A2J8NDM3

  15. XM_063795756.1 → XP_063651826.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

    UniProtKB/TrEMBL
    A0A2J8NDM3

  16. XM_054671681.2 → XP_054527656.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

  17. XM_054671679.2 → XP_054527654.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

  18. XM_054671677.2 → XP_054527652.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

  19. XM_016933795.4 → XP_016789284.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

    UniProtKB/TrEMBL
    A0A2I3RS67

  20. XM_009434066.5 → XP_009432341.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

    UniProtKB/TrEMBL
    A0A2I3REX5, A0A2I3RS67, A0A2J8NDK0, A0A663DCV3
    Related
    ENSPTRP00000062932.1
    Conserved Domains (6) summary
    smart00456
    Location:828 → 860
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:921 → 1250
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00201
    Location:779 → 809
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:666 → 695
    WW; WW domain
    cl14603
    Location:379 → 432
    C2; C2 domain
    cl26464
    Location:79 → 404
    Atrophin-1; Atrophin-1 family

  21. XM_054671675.2 → XP_054527650.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

  22. XM_009434068.5 → XP_009432343.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

    UniProtKB/TrEMBL
    A0A2I3RS67
    Conserved Domains (6) summary
    smart00456
    Location:808 → 840
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:901 → 1230
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:877 → 1231
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:759 → 789
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:646 → 675
    WW; WW domain
    cl14603
    Location:379 → 432
    C2; C2 domain

  23. XM_054671676.2 → XP_054527651.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

  24. XM_016933798.4 → XP_016789287.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

    UniProtKB/TrEMBL
    A0A2I3RS67

  25. XM_054671678.2 → XP_054527653.1  E3 ubiquitin-protein ligase NEDD4-like isoform X8

  26. XM_054671680.2 → XP_054527655.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

Nucleotide Protein
Heading Accession and Version

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