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FASN fatty acid synthase [ Pan troglodytes (chimpanzee) ]

Gene ID: 454986, updated on 10-Oct-2024

Summary

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Official Symbol
FASNprovided by VGNC
Official Full Name
fatty acid synthaseprovided by VGNC
Primary source
VGNC:VGNC:12131
Locus tag
CK820_G0047938
See related
Ensembl:ENSPTRG00000009791
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See FASN in Genome Data Viewer
Location:
chromosome: 19
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 19 NC_072417.2 (95430057..95450145, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 17 NC_072415.1 (93614364..93634364, complement)

Chromosome 19 - NC_072417.2Genomic Context describing neighboring genes Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1 like Neighboring gene coiled-coil domain containing 57 Neighboring gene small nucleolar RNA U13 Neighboring gene solute carrier family 16 member 3 Neighboring gene casein kinase 1 delta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fatty acid synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fatty acid synthase
XP_016786455.1
XP_016786456.1
XP_024206531.1
XP_063656119.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072417.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    95430057..95450145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024350763.3 → XP_024206531.1  fatty acid synthase isoform X2

    UniProtKB/TrEMBL
    K7AKK4, K7BZS1, K7DC51
    Conserved Domains (8) summary
    cd08954
    Location:1876 → 2112
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:2111 → 2179
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:1564 → 1854
    PKS_ER; Enoylreductase
    COG3321
    Location:1 → 1042
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    cd00833
    Location:2 → 404
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00975
    Location:2238 → 2497
    Thioesterase; Thioesterase domain
    pfam08242
    Location:1243 → 1342
    Methyltransf_12; Methyltransferase domain
    cl25409
    Location:1316 → 1522
    SDR; Short-chain dehydrogenases/reductases (SDR)

  2. XM_016930966.4 → XP_016786455.1  fatty acid synthase isoform X1

    UniProtKB/TrEMBL
    A0A2J8JFL4, A0A6D2WZ06, H2QE45, K7AKK4, K7BZS1, K7DMP5
    Conserved Domains (8) summary
    cd08954
    Location:1876 → 2112
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:2111 → 2179
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:1564 → 1854
    PKS_ER; Enoylreductase
    COG3321
    Location:1 → 1042
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    cd00833
    Location:2 → 404
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00975
    Location:2242 → 2501
    Thioesterase; Thioesterase domain
    pfam08242
    Location:1243 → 1342
    Methyltransf_12; Methyltransferase domain
    cl25409
    Location:1316 → 1522
    SDR; Short-chain dehydrogenases/reductases (SDR)

  3. XM_016930967.4 → XP_016786456.1  fatty acid synthase isoform X1

    UniProtKB/TrEMBL
    A0A2J8JFL4, A0A6D2WZ06, H2QE45, K7AKK4, K7BZS1, K7DMP5
    Related
    ENSPTRP00000016660.5
    Conserved Domains (8) summary
    cd08954
    Location:1876 → 2112
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:2111 → 2179
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:1564 → 1854
    PKS_ER; Enoylreductase
    COG3321
    Location:1 → 1042
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    cd00833
    Location:2 → 404
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00975
    Location:2242 → 2501
    Thioesterase; Thioesterase domain
    pfam08242
    Location:1243 → 1342
    Methyltransf_12; Methyltransferase domain
    cl25409
    Location:1316 → 1522
    SDR; Short-chain dehydrogenases/reductases (SDR)

  4. XM_063800049.1 → XP_063656119.1  fatty acid synthase isoform X2

    UniProtKB/TrEMBL
    K7DC51
Nucleotide Protein
Heading Accession and Version

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