RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: RFFLprovided by VGNC
Official Full Name: ring finger and FYVE like domain containing E3 ubiquitin protein ligaseprovided by VGNC
Primary source: VGNC:VGNC:14190
See related: Ensembl:ENSPTRG00000051761
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	19	NC_072417.2 (32515600..32596491)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	17	NC_072415.1 (30700692..30780948)

Chromosome 19 - NC_072417.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G29180 (e-PCR)
- UniSTS:41224

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

D17S822E (e-PCR)
- UniSTS:28243

L18426 (e-PCR)
- UniSTS:34648

D17S1725E (e-PCR)
- UniSTS:153959

D17S2135 (e-PCR)
- UniSTS:19816

RH48172 (e-PCR)
- UniSTS:19818

RH79802 (e-PCR)
- UniSTS:88688

A008R31 (e-PCR)
- UniSTS:25215

D11S3114 (e-PCR)
- UniSTS:152207

D17S1708 (e-PCR)
- UniSTS:40595

D17S822E (e-PCR)
- UniSTS:147373

WI-16693 (e-PCR)
- UniSTS:43953

A008P23 (e-PCR)
- UniSTS:43954

RH69286 (e-PCR)
- UniSTS:50876

SHGC-32545 (e-PCR)
- UniSTS:18631

G49586 (e-PCR)
- UniSTS:109255

GDB:631813 (e-PCR)
- UniSTS:158430

WI-15077 (e-PCR)
- UniSTS:7903

LIG3_3259 (e-PCR)
- UniSTS:462316

D17S822E (e-PCR)
- UniSTS:46839

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase rififylin

Names: rififylin; ring finger and FYVE-like domain containing 1

XP_001174509.1

EC 2.3.2.27

XP_016787489.1

EC 2.3.2.27

XP_016787491.1

EC 2.3.2.27

XP_016787492.1

EC 2.3.2.27

XP_016787493.1

EC 2.3.2.27

XP_063654771.1

EC 2.3.2.27

XP_063654772.1

EC 2.3.2.27

XP_063654773.1

EC 2.3.2.27

XP_063654774.1

EC 2.3.2.27

XP_063654775.1

EC 2.3.2.27

XP_063654776.1

EC 2.3.2.27

XP_063654777.1

EC 2.3.2.27

XP_063654778.1

EC 2.3.2.27

XP_063654779.1

EC 2.3.2.27

XP_063654780.1

EC 2.3.2.27

XP_063654781.1

EC 2.3.2.27

XP_063654782.1

EC 2.3.2.27

XP_063654783.1

EC 2.3.2.27

XP_063654784.1

EC 2.3.2.27

XP_063654785.1

EC 2.3.2.27

XP_063654786.1

EC 2.3.2.27

XP_063654787.1

EC 2.3.2.27

XP_063654788.1

EC 2.3.2.27

XP_063654789.1

EC 2.3.2.27

XP_063654790.1

EC 2.3.2.27

XP_063654791.1

EC 2.3.2.27

XP_063654792.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072417.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

32515600..32596491

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063798709.1 → XP_063654779.1 E3 ubiquitin-protein ligase rififylin isoform X2

UniProtKB/TrEMBL

H2QCP1
XM_063798717.1 → XP_063654787.1 E3 ubiquitin-protein ligase rififylin isoform X7

UniProtKB/TrEMBL

A0A2I3SKP3
XM_001174509.8 → XP_001174509.1 E3 ubiquitin-protein ligase rififylin isoform X2

See identical proteins and their annotated locations for XP_001174509.1

UniProtKB/TrEMBL

H2QCP1

Conserved Domains (2) summary

cd15770
Location:44 → 92

FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins

cd16500
Location:315 → 353

RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins
XM_063798711.1 → XP_063654781.1 E3 ubiquitin-protein ligase rififylin isoform X7

UniProtKB/TrEMBL

A0A2I3SKP3
XM_063798702.1 → XP_063654772.1 E3 ubiquitin-protein ligase rififylin isoform X2

UniProtKB/TrEMBL

H2QCP1
XM_063798710.1 → XP_063654780.1 E3 ubiquitin-protein ligase rififylin isoform X5
XM_063798721.1 → XP_063654791.1 E3 ubiquitin-protein ligase rififylin isoform X5
XM_063798712.1 → XP_063654782.1 E3 ubiquitin-protein ligase rififylin isoform X7

UniProtKB/TrEMBL

A0A2I3SKP3
XM_063798722.1 → XP_063654792.1 E3 ubiquitin-protein ligase rififylin isoform X8

UniProtKB/TrEMBL

A0A2I3RHV9
XM_063798704.1 → XP_063654774.1 E3 ubiquitin-protein ligase rififylin isoform X2

UniProtKB/TrEMBL

H2QCP1
XM_063798708.1 → XP_063654778.1 E3 ubiquitin-protein ligase rififylin isoform X2

UniProtKB/TrEMBL

H2QCP1
XM_063798707.1 → XP_063654777.1 E3 ubiquitin-protein ligase rififylin isoform X2

UniProtKB/TrEMBL

H2QCP1
XM_063798716.1 → XP_063654786.1 E3 ubiquitin-protein ligase rififylin isoform X7

UniProtKB/TrEMBL

A0A2I3SKP3
XM_063798714.1 → XP_063654784.1 E3 ubiquitin-protein ligase rififylin isoform X7

UniProtKB/TrEMBL

A0A2I3SKP3
XM_016932000.4 → XP_016787489.1 E3 ubiquitin-protein ligase rififylin isoform X1
XM_063798703.1 → XP_063654773.1 E3 ubiquitin-protein ligase rififylin isoform X2

UniProtKB/TrEMBL

H2QCP1
XM_063798713.1 → XP_063654783.1 E3 ubiquitin-protein ligase rififylin isoform X7

UniProtKB/TrEMBL

A0A2I3SKP3
XM_016932002.4 → XP_016787491.1 E3 ubiquitin-protein ligase rififylin isoform X3

Related

ENSPTRP00000077053.1
XM_016932003.4 → XP_016787492.1 E3 ubiquitin-protein ligase rififylin isoform X4
XM_016932004.4 → XP_016787493.1 E3 ubiquitin-protein ligase rififylin isoform X6
XM_063798720.1 → XP_063654790.1 E3 ubiquitin-protein ligase rififylin isoform X5
XM_063798706.1 → XP_063654776.1 E3 ubiquitin-protein ligase rififylin isoform X2

UniProtKB/TrEMBL

H2QCP1
XM_063798715.1 → XP_063654785.1 E3 ubiquitin-protein ligase rififylin isoform X7

UniProtKB/TrEMBL

A0A2I3SKP3
XM_063798705.1 → XP_063654775.1 E3 ubiquitin-protein ligase rififylin isoform X2

UniProtKB/TrEMBL

H2QCP1
XM_063798719.1 → XP_063654789.1 E3 ubiquitin-protein ligase rififylin isoform X5
XM_063798718.1 → XP_063654788.1 E3 ubiquitin-protein ligase rififylin isoform X8

UniProtKB/TrEMBL

A0A2I3RHV9
XM_063798701.1 → XP_063654771.1 E3 ubiquitin-protein ligase rififylin isoform X2

UniProtKB/TrEMBL

H2QCP1