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rfe UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase [ Mycobacterium canettii CIPT 140010059 ]

Gene ID: 45425276, updated on 10-Oct-2024

Summary

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Gene symbol
rfe
Gene description
UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase
Locus tag
MCAN_RS06935
Gene type
protein coding
Organism
Mycobacterium canettii CIPT 140010059 (strain: CIPT 140010059)
Lineage
Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Old locus tag
MCAN_13191
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Genomic context

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Sequence:
NC_015848.1 (1482762..1483976)

NC_015848.1Genomic Context describing neighboring genes Neighboring gene peptide chain release factor 1 Neighboring gene peptide chain release factor N(5)-glutamine methyltransferase Neighboring gene L-threonylcarbamoyladenylate synthase Neighboring gene ATP synthase subunit I Neighboring gene F0F1 ATP synthase subunit A Neighboring gene F0F1 ATP synthase subunit C

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_015848.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mycobacterial lipid II is composed of a complex mixture of modified muramyl and peptide moieties linked to decaprenyl phosphate. Mahapatra S, et al. J Bacteriol, 2005 Apr. PMID 15805521, Free PMC Article
  2. N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis. Huszár S, et al. Antimicrob Agents Chemother, 2017 Nov. PMID 28874370, Free PMC Article
  3. Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors. Mitachi K, et al. Anal Biochem, 2016 Nov 1. PMID 27530653, Free PMC Article
  4. Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45. Ishizaki Y, et al. J Biol Chem, 2013 Oct 18. PMID 23986448, Free PMC Article
  5. Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG_4947 have WecA function and MSMEG_4947 is required for the growth of M. smegmatis. Jin Y, et al. FEMS Microbiol Lett, 2010 Sep 1. PMID 20637039

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase
WP_003898816.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_015848.1 Reference assembly

    Range
    1482762..1483976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_003898816.1 MULTISPECIES: UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase [Mycobacterium]

    See identical proteins and their annotated locations for WP_003898816.1

    UniProtKB/Swiss-Prot
    L0T8Z6, P9WMW4, P9WMW5, Q10606
    UniProtKB/TrEMBL
    A0A045JVD7, A0A0H3L942, A0A8I0ENF4, A0AAP5BVP7, A5U201, R4M7I4
    Conserved Domains (1) summary
    cd06853
    Location:67 → 341
    GT_WecA_like; This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond ...
Nucleotide Protein
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