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WDR59 WD repeat domain 59 [ Pan troglodytes (chimpanzee) ]

Gene ID: 454244, updated on 10-Oct-2024

Summary

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Official Symbol
WDR59provided by VGNC
Official Full Name
WD repeat domain 59provided by VGNC
Primary source
VGNC:VGNC:5954
Locus tag
CK820_G0042740
See related
Ensembl:ENSPTRG00000008351
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See WDR59 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 18 NC_072416.2 (72981256..73093508, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 16 NC_072414.1 (72978963..73093368, complement)

Chromosome 18 - NC_072416.2Genomic Context describing neighboring genes Neighboring gene mixed lineage kinase domain like pseudokinase Neighboring gene fatty acid 2-hydroxylase Neighboring gene zinc and ring finger 1 Neighboring gene lactate dehydrogenase D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of Seh1-associated complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
WD repeat-containing protein 59; GATOR2 complex protein WDR59

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072416.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    72981256..73093508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016930174.3 → XP_016785663.1  GATOR2 complex protein WDR59 isoform X3

    UniProtKB/TrEMBL
    A0A2J8Q6F6, A0A6D2WG69, H2QBI5, K7BTM2, K7CBY7
    Related
    ENSPTRP00000014260.4
    Conserved Domains (4) summary
    smart00591
    Location:394 → 494
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    COG2319
    Location:34 → 328
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:922 → 968
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins

  2. XM_054668462.2 → XP_054524437.1  GATOR2 complex protein WDR59 isoform X4

  3. XM_016930173.3 → XP_016785662.1  GATOR2 complex protein WDR59 isoform X1

    UniProtKB/TrEMBL
    K7BTM2
    Conserved Domains (4) summary
    smart00591
    Location:394 → 494
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:62 → 103
    7WD40; WD40 repeat [structural motif]
    cd16692
    Location:941 → 987
    mRING-H2-C3H3C2_WDR59; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein 59 (WDR59) and similar proteins
    cl29593
    Location:100 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_063797434.1 → XP_063653504.1  GATOR2 complex protein WDR59 isoform X2

  5. XM_054668464.2 → XP_054524439.1  GATOR2 complex protein WDR59 isoform X6

  6. XM_016930175.4 → XP_016785664.1  GATOR2 complex protein WDR59 isoform X5

    UniProtKB/TrEMBL
    A0A2J8Q6D8

RNA

  1. XR_010152456.1 RNA Sequence

  2. XR_010152455.1 RNA Sequence

Nucleotide Protein
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