MYO1F myosin IF [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYO1Fprovided by HGNC
Official Full Name: myosin IFprovided by HGNC
Primary source: HGNC:HGNC:7600
See related: Ensembl:ENSG00000142347 MIM:601480; AllianceGenome:HGNC:7600
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]
Expression: Biased expression in bone marrow (RPKM 41.2), spleen (RPKM 33.9) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (8520778..8577442, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (8508359..8564804, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (8585662..8642326, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis.
Title: MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis.
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration.
Title: Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration.
NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis.
Title: NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis.
Mutations in MYO1F alters the mitochondrial network and induces tumor proliferation in thyroid cancer.
Title: Mutant MYO1F alters the mitochondrial network and induces tumor proliferation in thyroid cancer.
identification of 6 heterozygous missense mutations in MYO1C and additional 5 heterozygous missense mutations in MYO1F in bilateral sensorineural hearing loss
Title: Are MYO1C and MYO1F associated with hearing loss?
Observational study of gene-disease association. (HuGE Navigator)
Title: Are MYO1C and MYO1F associated with hearing loss?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed
Many sequence variants affecting diversity of adult human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of myosin IF (MYO1F) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19S391 (e-PCR)
- UniSTS:48445

MYO1F_8481 (e-PCR)
- UniSTS:467785

RH65685 (e-PCR)
- UniSTS:56450

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	NAS Non-traceable Author Statement more info	PubMed
enables actin binding	NAS Non-traceable Author Statement more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of unconventional myosin complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: unconventional myosin-If

Names: myosin-ID; myosin-Ie

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052844.1 RefSeqGene

Range

5006..61670

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001348355.2 → NP_001335284.1 unconventional myosin-If isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC092298, AC092316, AC130469

UniProtKB/TrEMBL

B0I1T1

Conserved Domains (4) summary

cd11827
Location:1041 → 1093

SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins

cd01378
Location:31 → 673

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:713 → 911

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

cl26464
Location:954 → 1039

Atrophin-1; Atrophin-1 family
NM_012335.4 → NP_036467.2 unconventional myosin-If isoform 1

See identical proteins and their annotated locations for NP_036467.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB210037, AC092298, BC028071, DA380582

Consensus CDS

CCDS42494.1

UniProtKB/Swiss-Prot

O00160, Q8WWN7

UniProtKB/TrEMBL

B0I1T1

Related

ENSP00000494550.1, ENST00000644032.2

Conserved Domains (4) summary

cd11827
Location:1045 → 1097

SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins

cd01378
Location:31 → 677

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:717 → 915

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

cl26464
Location:958 → 1043

Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

8520778..8577442 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528027.3 → XP_011526329.1 unconventional myosin-If isoform X2

UniProtKB/TrEMBL

B0I1T1

Conserved Domains (4) summary

cd11827
Location:1021 → 1073

SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins

smart00242
Location:12 → 666

MYSc; Myosin. Large ATPases

cl22853
Location:31 → 653

Motor_domain; Myosin and Kinesin motor domain

pfam06017
Location:693 → 873

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_011528024.3 → XP_011526326.1 unconventional myosin-If isoform X1

UniProtKB/TrEMBL

B0I1T1

Conserved Domains (4) summary

cd11827
Location:1066 → 1118

SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins

smart00242
Location:12 → 711

MYSc; Myosin. Large ATPases

cd01378
Location:31 → 698

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:738 → 918

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_047438852.1 → XP_047294808.1 unconventional myosin-If isoform X3
XM_011528028.4 → XP_011526330.1 unconventional myosin-If isoform X4

Conserved Domains (2) summary

smart00242
Location:12 → 508

MYSc; Myosin. Large ATPases

cl22853
Location:31 → 508

Motor_domain; Myosin and Kinesin motor domain