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CCR5 C-C motif chemokine receptor 5 [ Pan troglodytes (chimpanzee) ]

Gene ID: 450128, updated on 10-Oct-2024

Summary

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Official Symbol
CCR5provided by VGNC
Official Full Name
C-C motif chemokine receptor 5provided by VGNC
Primary source
VGNC:VGNC:11366
Locus tag
CK820_G0005233
See related
Ensembl:ENSPTRG00000014848
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human all
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Genomic context

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See CCR5 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 2 NC_086015.1 (50385079..50390439)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 3 NC_072401.1 (50386705..50387763)

Chromosome 2 - NC_086015.1Genomic Context describing neighboring genes Neighboring gene cytochrome b-c1 complex subunit 2, mitochondrial-like Neighboring gene C-C motif chemokine receptor 2 Neighboring gene uncharacterized LOC104005543 Neighboring gene C-C motif chemokine receptor like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence of chemokine receptor gene CCR5 in chimpanzees, a natural HIV type 1 host. Zacharova V, et al. AIDS Res Hum Retroviruses, 1997 Sep 1. PMID 9282822
  2. Sequence evolution of the CCR5 chemokine receptor gene in primates. Zhang YW, et al. Mol Biol Evol, 1999 Sep. PMID 10486970
  3. Chimpanzee CXCR4 and CCR5 act as coreceptors for HIV type 1. Prétet JL, et al. AIDS Res Hum Retroviruses, 1997 Dec 10. PMID 9430250
  4. HIV type 1 subtypes, coreceptor usage, and CCR5 polymorphism. Zhang L, et al. AIDS Res Hum Retroviruses, 1997 Nov 1. PMID 9359654
  5. Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthropoidea. Kunstman KJ, et al. J Virol, 2003 Nov. PMID 14581567, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables C-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chemokine (C-C motif) ligand 5 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
C-C chemokine receptor type 5
Names
C-C CKR-5
C-C chemokine receptor 5
CC chemokine receptor type 5
CC-CKR-5
CC-chemokine receptor 5
CCR-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009046.1 → NP_001009046.1  C-C chemokine receptor type 5

    See identical proteins and their annotated locations for NP_001009046.1

    Status: PROVISIONAL

    Source sequence(s)
    AF177894
    UniProtKB/Swiss-Prot
    O02778, P56440
    UniProtKB/TrEMBL
    A0A0E3T4M2, A0A2J8PAG3, A0A2L2P6L9
    Related
    ENSPTRP00000025599.5, ENSPTRT00000027757.6
    Conserved Domains (1) summary
    cd15184
    Location:31 → 308
    7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    50385079..50390439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063805076.1 → XP_063661146.1  C-C chemokine receptor type 5 isoform X1

    UniProtKB/Swiss-Prot
    O02778, P56440
    UniProtKB/TrEMBL
    A0A2J8PAG3, A0A2L2P6L9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56440.1 GenPept UniProtKB/Swiss-Prot:P56440

Gene LinkOut

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Molecular Biology Databases
Research Materials