rad51c RAD51 paralog C [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rad51cprovided by ZNC
Official Full Name: RAD51 paralog Cprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-204
See related: Ensembl:ENSDARG00000068919 AllianceGenome:ZFIN:ZDB-GENE-041010-204
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fanco; zgc:101596
Summary: Predicted to enable ATP binding activity; ATP-dependent activity, acting on DNA; and DNA binding activity. Predicted to contribute to crossover junction endodeoxyribonuclease activity and four-way junction DNA binding activity. Predicted to be involved in meiotic DNA recombinase assembly and reciprocal meiotic recombination. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex and Rad51C-XRCC3 complex. Predicted to be active in replication fork. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (32663180..32673149)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (32719320..32728540)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to crossover junction DNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to four-way junction DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leukocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic DNA recombinase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rad51C-XRCC3 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA repair protein RAD51 homolog 3

Names: rad51 homolog C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006101.1 → NP_001006101.1 DNA repair protein RAD51 homolog 3

See identical proteins and their annotated locations for NP_001006101.1

Status: PROVISIONAL

Source sequence(s)

BC083214

UniProtKB/TrEMBL

Q5XJT2

Related

ENSDARP00000090614.2, ENSDART00000099841.5

Conserved Domains (2) summary

PRK04301
Location:3 → 331

radA; DNA repair and recombination protein RadA; Validated

cd01123
Location:86 → 330

Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

32663180..32673149

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479165.2 → XP_021334840.1 DNA repair protein RAD51 homolog 3 isoform X2

UniProtKB/TrEMBL

A0A8M9QKP1

Conserved Domains (1) summary

cd01123
Location:86 → 305

Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...
XM_021479164.2 → XP_021334839.1 DNA repair protein RAD51 homolog 3 isoform X1

UniProtKB/TrEMBL

A0A8M9QC24

Conserved Domains (1) summary

cd01123
Location:86 → 330

Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...