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gins1 GINS complex subunit 1 (Psf1 homolog) [ Danio rerio (zebrafish) ]

Gene ID: 450061, updated on 12-Sep-2024

Summary

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Official Symbol
gins1provided by ZNC
Official Full Name
GINS complex subunit 1 (Psf1 homolog)provided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-184
See related
Ensembl:ENSDARG00000007624 AllianceGenome:ZFIN:ZDB-GENE-041010-184
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:101672
Summary
Predicted to be involved in DNA strand elongation involved in mitotic DNA replication. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleus. Predicted to be part of GINS complex. Is expressed in proliferative region. Human ortholog(s) of this gene implicated in immunodeficiency 55. Orthologous to human GINS1 (GINS complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See gins1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (7164345..7170352)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (9852873..9858880)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487361 Neighboring gene uncharacterized LOC137487362 Neighboring gene ribosomal protein S6 kinase, polypeptide 2 Neighboring gene ninein-like Neighboring gene AIF family member 2 Neighboring gene uncharacterized LOC137487363 Neighboring gene neuroblast differentiation-associated protein AHNAK-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Tissue-Specific Requirement for the GINS Complex During Zebrafish Development. Varga M, et al. Front Cell Dev Biol, 2020. PMID 32548116, Free PMC Article
  2. Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. Kuil LE, et al. Elife, 2020 May 5. PMID 32367800, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand elongation involved in mitotic DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GINS complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA replication complex GINS protein PSF1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006081.1 → NP_001006081.1  DNA replication complex GINS protein PSF1

    See identical proteins and their annotated locations for NP_001006081.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083239
    UniProtKB/TrEMBL
    Q5XJQ9
    Related
    ENSDARP00000017647.7, ENSDART00000022051.9
    Conserved Domains (2) summary
    cd11710
    Location:3 → 130
    GINS_A_psf1; Alpha-helical domain of GINS complex protein Psf1
    COG5230
    Location:1 → 191
    COG5230; Uncharacterized conserved protein [Function unknown]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    7164345..7170352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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