chga chromogranin A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chgaprovided by ZNC
Official Full Name: chromogranin Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-161
See related: Ensembl:ENSDARG00000008829 AllianceGenome:ZFIN:ZDB-GENE-041010-161
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj05f09; zgc:56075; wu:fj05f09; zgc:101749; si:dkey-177p2.2
Summary: Predicted to be involved in adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation; defense response to bacterium; and negative regulation of secretion by cell. Predicted to be located in extracellular region. Predicted to be active in chromaffin granule and extracellular space. Is expressed in nervous system; otic vesicle; trigeminal placode; and trunk neural crest. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypertension; and prostate cancer. Orthologous to human CHGA (chromogranin A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (27020201..27046006)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (27121105..27146916)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study indicates that chga may play an important role in nervous system development during the early embryonic stages.
Title: Spatio-temporal expression of chromogranin A during zebrafish embryogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of catecholamine secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin secretion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in chromaffin granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IEA Inferred from Electronic Annotation more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chromogranin-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006059.2 → NP_001006059.2 chromogranin-A precursor

Status: VALIDATED

Source sequence(s)

BX248515, CK027054, DT865424, EH463078

UniProtKB/TrEMBL

A0A8M1N2U5, Q5RIJ8

Related

ENSDARP00000022142.5, ENSDART00000016014.6

Conserved Domains (1) summary

pfam01271
Location:34 → 339

Granin; Granin (chromogranin or secretogranin)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

27020201..27046006

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160561.5 → XP_005160618.1 chromogranin-A isoform X1

UniProtKB/TrEMBL

A0A8M2B7N6

Conserved Domains (1) summary

pfam01271
Location:34 → 338

Granin; Granin (chromogranin or secretogranin)