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eef2kmt eukaryotic elongation factor 2 lysine methyltransferase [ Danio rerio (zebrafish) ]

Gene ID: 450038, updated on 18-Sep-2024

Summary

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Official Symbol
eef2kmtprovided by ZNC
Official Full Name
eukaryotic elongation factor 2 lysine methyltransferaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-160
See related
Ensembl:ENSDARG00000054950 AllianceGenome:ZFIN:ZDB-GENE-041010-160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fam86a; zgc:101751
Summary
Predicted to enable methyltransferase activity. Predicted to act upstream of or within methylation. Orthologous to human EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See eef2kmt in Genome Data Viewer
Location:
chromosome: 3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (28869610..28872761, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (28738768..28742088, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 70 Neighboring gene si:ch211-76l23.7 Neighboring gene ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase Neighboring gene uncharacterized LOC101885742 Neighboring gene lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. Liu Z, et al. J Biol Chem, 2011 Aug 12. PMID 21669877, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein-lysine N-methyltransferase EEF2KMT
Names
family with sequence similarity 86, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006058.2 → NP_001006058.2  protein-lysine N-methyltransferase EEF2KMT isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX510989
    UniProtKB/TrEMBL
    Q5XJN3
    Related
    ENSDARP00000116881.1, ENSDART00000138840.2

  2. NM_001430946.1 → NP_001417875.1  protein-lysine N-methyltransferase EEF2KMT isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX510989
    UniProtKB/TrEMBL
    A0A8M3B8A5, Q5XJN3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    28869610..28872761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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