tars1 threonyl-tRNA synthetase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tars1provided by ZNC
Official Full Name: threonyl-tRNA synthetase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-218
See related: Ensembl:ENSDARG00000013250 AllianceGenome:ZFIN:ZDB-GENE-041010-218
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tars; ThrRS; zgc:92586; wu:fb07c05; wu:fb39c12
Summary: Predicted to enable threonine-tRNA ligase activity. Acts upstream of or within branching involved in blood vessel morphogenesis and regulation of sprouting angiogenesis. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; brain; digestive system; optic vesicle; and segmental plate. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 7. Orthologous to human TARS1 (threonyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (44346742..44371173)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (43746589..43771020)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

noncanonical function of tars regulates vascular development presumably by modulating the expression of vegfa
Title: Noncanonical function of threonyl-tRNA synthetase regulates vascular development in zebrafish.
Mutations in threonyl tRNA synthetase (tars(y58)) leads to increased branching angiogenesis in developing zebrafish.
Title: Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

fb39c12.x1 (e-PCR)
- UniSTS:203188

fb07c05.x1 (e-PCR)
- UniSTS:202728

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables threonine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables threonine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in threonyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within threonyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: threonine--tRNA ligase 1, cytoplasmic

Names: threonine--tRNA ligase

NP_001005932.1

EC 6.1.1.3

NP_001116258.1

EC 6.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005932.2 → NP_001005932.1 threonine--tRNA ligase 1, cytoplasmic isoform 2

See identical proteins and their annotated locations for NP_001005932.1

Status: PROVISIONAL

Source sequence(s)

BC083525

UniProtKB/TrEMBL

Q5XIZ3

Conserved Domains (5) summary

cd01667
Location:78 → 139

TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...

PLN02908
Location:46 → 617

PLN02908; threonyl-tRNA synthetase

smart00863
Location:245 → 292

tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

cd00771
Location:300 → 519

ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...

cd00860
Location:519 → 610

ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
NM_001122786.1 → NP_001116258.1 threonine--tRNA ligase 1, cytoplasmic isoform 1

See identical proteins and their annotated locations for NP_001116258.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

BC154371

UniProtKB/TrEMBL

A8KC60

Related

ENSDARP00000036825.6, ENSDART00000034523.8

Conserved Domains (5) summary

cd01667
Location:78 → 139

TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...

PLN02908
Location:32 → 711

PLN02908; threonyl-tRNA synthetase

smart00863
Location:245 → 292

tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

cd00771
Location:316 → 613

ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...

cd00860
Location:613 → 704

ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...