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osbpl7 oxysterol binding protein-like 7 [ Danio rerio (zebrafish) ]

Gene ID: 449656, updated on 12-Sep-2024

Summary

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Official Symbol
osbpl7provided by ZNC
Official Full Name
oxysterol binding protein-like 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-212
See related
Ensembl:ENSDARG00000012981 AllianceGenome:ZFIN:ZDB-GENE-041010-212
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
osbpl6; zgc:92595; wu:fu06e07
Summary
Predicted to enable cholesterol binding activity and sterol transporter activity. Predicted to act upstream of or within lipid transport. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Is expressed in EVL; epidermis; periderm; pharynx; and retina. Orthologous to human OSBPL7 (oxysterol binding protein like 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See osbpl7 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (28773589..28794976, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (28657652..28680173, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene TANK-binding kinase 1-binding protein 1-like Neighboring gene T-box transcription factor 21 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene pyridoxamine 5'-phosphate oxidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio. Mitra S, et al. FEBS J, 2010 Jan. PMID 19961539
  2. A vertebrate model for the study of lipid binding/transfer protein function: conservation of OSBP-related proteins between zebrafish and human. Zhou Y, et al. Biochem Biophys Res Commun, 2014 Apr 11. PMID 24326072
  3. Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes. Sundström G, et al. Gen Comp Endocrinol, 2008 Feb 1. PMID 17950734
  4. Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters. Sundström G, et al. BMC Evol Biol, 2008 Sep 19. PMID 18803835, Free PMC Article
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oxysterol-binding protein-related protein 7
Names
oxysterol binding protein-like 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005927.1 → NP_001005927.1  oxysterol-binding protein-related protein 7

    See identical proteins and their annotated locations for NP_001005927.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083531
    UniProtKB/TrEMBL
    Q5XIY7
    Related
    ENSDARP00000013230.7, ENSDART00000020667.9
    Conserved Domains (3) summary
    cd13287
    Location:41 → 170
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:70 → 160
    PH; PH domain
    pfam01237
    Location:523 → 865
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    28773589..28794976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224543.1 → XP_068080644.1  oxysterol-binding protein-related protein 7 isoform X4

  2. XM_009306608.4 → XP_009304883.1  oxysterol-binding protein-related protein 7 isoform X1

    See identical proteins and their annotated locations for XP_009304883.1

    UniProtKB/TrEMBL
    A0A8M3BE40
    Conserved Domains (3) summary
    cd13287
    Location:41 → 170
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:70 → 160
    PH; PH domain
    pfam01237
    Location:545 → 887
    Oxysterol_BP; Oxysterol-binding protein

  3. XM_009306611.4 → XP_009304886.1  oxysterol-binding protein-related protein 7 isoform X6

    UniProtKB/TrEMBL
    A0A8M3B4J5
    Conserved Domains (3) summary
    cd13287
    Location:41 → 170
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:70 → 160
    PH; PH domain
    pfam01237
    Location:492 → 834
    Oxysterol_BP; Oxysterol-binding protein

  4. XM_009306609.4 → XP_009304884.1  oxysterol-binding protein-related protein 7 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AY80
    Conserved Domains (3) summary
    cd13287
    Location:41 → 170
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:70 → 160
    PH; PH domain
    pfam01237
    Location:531 → 873
    Oxysterol_BP; Oxysterol-binding protein

  5. XM_021480054.2 → XP_021335729.1  oxysterol-binding protein-related protein 7 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QE65
    Conserved Domains (2) summary
    cd13287
    Location:41 → 170
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:537 → 879
    Oxysterol_BP; Oxysterol-binding protein

  6. XM_009306610.4 → XP_009304885.1  oxysterol-binding protein-related protein 7 isoform X5

    UniProtKB/TrEMBL
    A0A8M3B7C6
    Conserved Domains (3) summary
    cd13287
    Location:41 → 170
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:70 → 160
    PH; PH domain
    pfam01237
    Location:514 → 856
    Oxysterol_BP; Oxysterol-binding protein

  7. XM_009306607.4 → XP_009304882.1  oxysterol-binding protein-related protein 7 isoform X1

    See identical proteins and their annotated locations for XP_009304882.1

    UniProtKB/TrEMBL
    A0A8M3BE40
    Conserved Domains (3) summary
    cd13287
    Location:41 → 170
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:70 → 160
    PH; PH domain
    pfam01237
    Location:545 → 887
    Oxysterol_BP; Oxysterol-binding protein

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394848.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    216074..237241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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