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DRD4 dopamine receptor D4 [ Pan troglodytes (chimpanzee) ]

Gene ID: 449578, updated on 17-Aug-2024

Summary

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Official Symbol
DRD4provided by VGNC
Official Full Name
dopamine receptor D4provided by VGNC
Primary source
VGNC:VGNC:11343
Locus tag
CK820_G0044155
See related
Ensembl:ENSPTRG00000003128
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See DRD4 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 9 NC_072407.2 (4834831..4841639)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 11 NC_072409.1 (4754971..4760751)

Chromosome 9 - NC_072407.2Genomic Context describing neighboring genes Neighboring gene cadherin related family member 5 Neighboring gene secretin Neighboring gene DEAF1 transcription factor Neighboring gene transmembrane protein 80 Neighboring gene EPS8 signaling adaptor L2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4). Seaman MI, et al. Am J Med Genet, 1999 Dec 15. PMID 10581493
  2. Re: The questionable implications of the dopamine D4 receptor (DRD4) gene tree for primate phylogeny. Ruvolo M, et al. Mol Phylogenet Evol, 1996 Apr. PMID 8728402
  3. Variability of dopamine D4 receptor (DRD4) gene sequence within and among nonhuman primate species. Livak KJ, et al. Proc Natl Acad Sci U S A, 1995 Jan 17. PMID 7831304, Free PMC Article
  4. Polymorphism in the second intron of dopamine receptor D4 gene in humans and apes. Shimada MK, et al. Biochem Biophys Res Commun, 2004 Apr 16. PMID 15044110
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipase C-activating dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
D(4) dopamine receptor
Names
dopamine D4 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072407.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    4834831..4841639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016920015.3 → XP_016775504.1  D(4) dopamine receptor

    UniProtKB/TrEMBL
    A0A2J8JVS5, H2Q2V4
    Related
    ENSPTRP00000005517.4
    Conserved Domains (2) summary
    cd15308
    Location:38 → 423
    7tmA_D4_dopamine_R; D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl26464
    Location:260 → 356
    Atrophin-1; Atrophin-1 family
Nucleotide Protein
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