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cnot3a CCR4-NOT transcription complex, subunit 3a [ Danio rerio (zebrafish) ]

Gene ID: 449540, updated on 2-Nov-2024

Summary

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Official Symbol
cnot3aprovided by ZNC
Official Full Name
CCR4-NOT transcription complex, subunit 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040927-6
See related
Ensembl:ENSDARG00000007135 AllianceGenome:ZFIN:ZDB-GENE-040927-6
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cnot3; fb73b06; fc17h07; zgc:92813; wu:fb73b06; wu:fc17h07
Summary
Acts upstream of or within digestive tract development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including gut; head; heart; integument; and testis. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See cnot3a in Genome Data Viewer
Location:
chromosome: 16
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (32110195..32128345, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (32156165..32174333, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene PRP31 pre-mRNA processing factor 31 homolog (yeast) Neighboring gene uncharacterized LOC137487923 Neighboring gene sphingosine kinase 2 Neighboring gene G protein-coupled receptor, class C, group 6, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas. Delacruz RGC, et al. Oncotarget, 2019 Jun 11. PMID 31231471, Free PMC Article
  2. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of stem cell population maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCR4-NOT core complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit 3a
Names
CCR4-NOT transcription complex, subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328118.1 → NP_001315047.1  CCR4-NOT transcription complex subunit 3a

    Status: VALIDATED

    Source sequence(s)
    CR854927
    UniProtKB/TrEMBL
    A0A8M1P9K0, F1Q4L8
    Related
    ENSDARP00000092876.3, ENSDART00000102100.3
    Conserved Domains (2) summary
    pfam04065
    Location:3 → 229
    Not3; Not1 N-terminal domain, CCR4-Not complex component
    pfam04153
    Location:779 → 900
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    32110195..32128345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466678.2 → XP_021322353.1  CCR4-NOT transcription complex subunit 3a isoform X1

    UniProtKB/TrEMBL
    A0A8M9P7W2
    Conserved Domains (3) summary
    pfam04065
    Location:3 → 227
    Not3; Not1 N-terminal domain, CCR4-Not complex component
    pfam04153
    Location:773 → 898
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
    cl26464
    Location:536 → 821
    Atrophin-1; Atrophin-1 family

  2. XM_005158349.5 → XP_005158406.1  CCR4-NOT transcription complex subunit 3a isoform X2

    UniProtKB/TrEMBL
    A0A8M2B4P9, E9QGK5
    Related
    ENSDARP00000118084.1, ENSDART00000137699.3
    Conserved Domains (2) summary
    pfam04065
    Location:3 → 229
    Not3; Not1 N-terminal domain, CCR4-Not complex component
    pfam04153
    Location:772 → 893
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001005582.1: Suppressed sequence

    Description
    NM_001005582.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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