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RUNX2 RUNX family transcription factor 2 [ Canis lupus familiaris (dog) ]

Gene ID: 449531, updated on 17-Aug-2024

Summary

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Official Symbol
RUNX2provided by VGNC
Official Full Name
RUNX family transcription factor 2provided by VGNC
Primary source
VGNC:VGNC:111707
See related
Ensembl:ENSCAFG00845012369
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See RUNX2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (14116775..14343464)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (13657403..13875716)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (13825170..14151515)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (13641535..13967483)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (13729537..14055648)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene SPT3 homolog, SAGA and STAGA complex component Neighboring gene uncharacterized LOC111098272 Neighboring gene uncharacterized LOC119874172 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC111098268 Neighboring gene uncharacterized LOC111098273 Neighboring gene uncharacterized LOC102156578 Neighboring gene uncharacterized LOC111098269 Neighboring gene uncharacterized LOC102156644

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Enhancement of Runx2 expression is potentially linked to β-catenin accumulation in canine intervertebral disc degeneration. Iwata M, et al. J Cell Physiol, 2015 Jan. PMID 24916026
  2. Evaluation of the association between runt-related transcription factor 2 expression and intervertebral disk aging in dogs. Itoh H, et al. Am J Vet Res, 2012 Oct. PMID 23013180
  3. The differentially DNA-methylated region responsible for expression of runt-related transcription factor 2. Wakitani S, et al. J Vet Med Sci, 2017 Feb 4. PMID 27916785, Free PMC Article
  4. Molecular origins of rapid and continuous morphological evolution. Fondon JW 3rd, et al. Proc Natl Acad Sci U S A, 2004 Dec 28. PMID 15596718, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identified a novel genomic region in which DNA methylation status is related to Runx2 expression and detected demethylation of Runx2-DMR during osteoblastic differentiation in mouse and dog.
    Title: The differentially DNA-methylated region responsible for expression of runt-related transcription factor 2.
  2. Runx2 transcript and protein expression, potentially in combination with beta-catenin accumulation, are enhanced in degenerated and calcified intervertebral discs of chondrodystrophic dog breeds
    Title: Enhancement of Runx2 expression is potentially linked to β-catenin accumulation in canine intervertebral disc degeneration.
  3. RUNX2 mRNA and protein expression in the nucleus pulposus are enhanced in aging intervertebral disks in dogs.
    Title: Evaluation of the association between runt-related transcription factor 2 expression and intervertebral disk aging in dogs.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
runt-related transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    14116775..14343464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038683679.1 → XP_038539607.1  runt-related transcription factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0ML87
    Related
    ENSCAFP00845017437.1, ENSCAFT00845022178.1
    Conserved Domains (3) summary
    pfam05109
    Location:329 → 517
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00853
    Location:168 → 294
    Runt; Runt domain
    pfam08504
    Location:471 → 562
    RunxI; Runx inhibition domain

  2. XM_038683677.1 → XP_038539605.1  runt-related transcription factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0ML87
    Conserved Domains (3) summary
    pfam05109
    Location:329 → 539
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00853
    Location:168 → 294
    Runt; Runt domain
    pfam08504
    Location:493 → 584
    RunxI; Runx inhibition domain

  3. XM_038683678.1 → XP_038539606.1  runt-related transcription factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NCM7, A0A8P0NSZ1
    Related
    ENSCAFP00845017425.1, ENSCAFT00845022161.1
    Conserved Domains (3) summary
    pfam05109
    Location:311 → 521
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00853
    Location:150 → 276
    Runt; Runt domain
    pfam08504
    Location:475 → 566
    RunxI; Runx inhibition domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    13641535..13967483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038491957.1 → XP_038347885.1  runt-related transcription factor 2 isoform X6

  2. XM_038491961.1 → XP_038347889.1  runt-related transcription factor 2 isoform X9

  3. XM_038491958.1 → XP_038347886.1  runt-related transcription factor 2 isoform X7

  4. XM_038491960.1 → XP_038347888.1  runt-related transcription factor 2 isoform X8

  5. XM_038491959.1 → XP_038347887.1  runt-related transcription factor 2 isoform X8

  6. XM_038491956.1 → XP_038347884.1  runt-related transcription factor 2 isoform X5

  7. XM_038491955.1 → XP_038347883.1  runt-related transcription factor 2 isoform X4

  8. XM_038491954.1 → XP_038347882.1  runt-related transcription factor 2 isoform X3

  9. XM_038491951.1 → XP_038347879.1  runt-related transcription factor 2 isoform X1

  10. XM_038491952.1 → XP_038347880.1  runt-related transcription factor 2 isoform X2

RNA

  1. XR_005334033.1 RNA Sequence

  2. XR_005334034.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    13729537..14055648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038618085.1 → XP_038474013.1  runt-related transcription factor 2 isoform X12

  2. XM_038618090.1 → XP_038474018.1  runt-related transcription factor 2 isoform X15

  3. XM_038618086.1 → XP_038474014.1  runt-related transcription factor 2 isoform X13

  4. XM_038618089.1 → XP_038474017.1  runt-related transcription factor 2 isoform X14

  5. XM_038618088.1 → XP_038474016.1  runt-related transcription factor 2 isoform X14

  6. XM_038618084.1 → XP_038474012.1  runt-related transcription factor 2 isoform X11

  7. XM_038618083.1 → XP_038474011.1  runt-related transcription factor 2 isoform X10

  8. XM_038618082.1 → XP_038474010.1  runt-related transcription factor 2 isoform X3

  9. XM_038618080.1 → XP_038474008.1  runt-related transcription factor 2 isoform X1

  10. XM_038618081.1 → XP_038474009.1  runt-related transcription factor 2 isoform X2

RNA

  1. XR_005402142.1 RNA Sequence

  2. XR_005402143.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    13825170..14151515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038554219.1 → XP_038410147.1  runt-related transcription factor 2 isoform X18

    UniProtKB/TrEMBL
    A0A8I3NIZ2, A0A8P0PGC0

  2. XM_038554223.1 → XP_038410151.1  runt-related transcription factor 2 isoform X21

  3. XM_038554220.1 → XP_038410148.1  runt-related transcription factor 2 isoform X19

  4. XM_038554222.1 → XP_038410150.1  runt-related transcription factor 2 isoform X20

  5. XM_038554221.1 → XP_038410149.1  runt-related transcription factor 2 isoform X20

  6. XM_038554218.1 → XP_038410146.1  runt-related transcription factor 2 isoform X17

    UniProtKB/TrEMBL
    A0A8C0ML87

  7. XM_038554216.1 → XP_038410144.1  runt-related transcription factor 2 isoform X16

    UniProtKB/TrEMBL
    A0A8C0ML87

  8. XM_038554215.1 → XP_038410143.1  runt-related transcription factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0ML87

  9. XM_038554213.1 → XP_038410141.1  runt-related transcription factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0ML87, A0A8C0SD20

  10. XM_038554214.1 → XP_038410142.1  runt-related transcription factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SD73

RNA

  1. XR_005367770.1 RNA Sequence

  2. XR_005367771.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    13657403..13875716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038673596.1 → XP_038529524.1  runt-related transcription factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0ML87
    Conserved Domains (3) summary
    pfam05109
    Location:329 → 517
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00853
    Location:168 → 294
    Runt; Runt domain
    pfam08504
    Location:471 → 562
    RunxI; Runx inhibition domain

  2. XM_038673582.1 → XP_038529510.1  runt-related transcription factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0ML87
    Conserved Domains (3) summary
    pfam05109
    Location:329 → 539
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00853
    Location:168 → 294
    Runt; Runt domain
    pfam08504
    Location:493 → 584
    RunxI; Runx inhibition domain

  3. XM_038673587.1 → XP_038529515.1  runt-related transcription factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NCM7, A0A8P0NSZ1
    Conserved Domains (3) summary
    pfam05109
    Location:311 → 521
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00853
    Location:150 → 276
    Runt; Runt domain
    pfam08504
    Location:475 → 566
    RunxI; Runx inhibition domain
Nucleotide Protein
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