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MCAM melanoma cell adhesion molecule [ Gallus gallus (chicken) ]

Gene ID: 448832, updated on 17-Aug-2024

Summary

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Official Symbol
MCAMprovided by CGNC
Official Full Name
melanoma cell adhesion moleculeprovided by CGNC
Primary source
CGNC:54317
See related
Ensembl:ENSGALG00010024116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
MUC18; mucin-18
Annotation information
Annotation category: suggests misassembly
Orthologs
human mouse all
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Genomic context

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See MCAM in Genome Data Viewer
Location:
chromosome: 24
Exon count:
15
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 24 NC_052555.1 (4266882..4274784)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 24 NC_052596.1 (4226347..4234254)

Chromosome 24 - NC_052555.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417377 Neighboring gene ring finger protein 26 Neighboring gene Cbl proto-oncogene Neighboring gene coiled-coil domain containing 153 Neighboring gene PDZ domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neurite extension of DRG neurons by gicerin expression is enhanced by nerve growth factor. Hiroi S, et al. Int J Mol Med, 2005 Dec. PMID 16273279
  2. HEMCAM, an adhesion molecule expressed by c-kit+ hemopoietic progenitors. Vainio O, et al. J Cell Biol, 1996 Dec. PMID 8978830, Free PMC Article
  3. Molecular cloning and functional expression of gicerin, a novel cell adhesion molecule that binds to neurite outgrowth factor. Taira E, et al. Neuron, 1994 Apr. PMID 8161457
  4. Expression and functional analysis of a novel isoform of gicerin, an immunoglobulin superfamily cell adhesion molecule. Taira E, et al. J Biol Chem, 1995 Dec 1. PMID 7499388
  5. Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor. Guezguez B, et al. J Immunol, 2007 Nov 15. PMID 17982057

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MCAM might be involved in the recruitment of activated T cells to inflammation sites.
    Title: Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor.
  2. These results indicate that NGF might therefore enhance the expression of gicerin in DRG, thereby promoting the gicerin-dependent neurite extension during sciatic nerve regeneration.
    Title: Neurite extension of DRG neurons by gicerin expression is enhanced by nerve growth factor.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cell surface glycoprotein MUC18
Names
HEMCAM
gicerin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396032.1 → NP_001382961.1  cell surface glycoprotein MUC18 precursor 1 precursor

    Status: VALIDATED

    Source sequence(s)
    BM489731, BU127054, BU260394, CD218325, D38559, D49849, DN929995, Y08855, Y08856
    UniProtKB/TrEMBL
    A0A1D5PL70
    Related
    ENSGALP00010035806.1, ENSGALT00010058841.1
    Conserved Domains (3) summary
    smart00409
    Location:277 → 356
    IG; Immunoglobulin
    cd00096
    Location:170 → 175
    Ig; Ig strand B [structural motif]
    cl11960
    Location:164 → 257
    Ig; Immunoglobulin domain

  2. NM_001396033.1 → NP_001382962.1  cell surface glycoprotein MUC18 precursor 2 precursor

    Status: VALIDATED

    Source sequence(s)
    BM489731, BU127054, BU260394, CD218325, D38559, D49849, DN929995, Y08856
    UniProtKB/TrEMBL
    A0A8V0ZZV8
    Related
    ENSGALP00010035818.1, ENSGALT00010058853.1
    Conserved Domains (3) summary
    smart00409
    Location:277 → 356
    IG; Immunoglobulin
    cd00096
    Location:170 → 175
    Ig; Ig strand B [structural motif]
    cl11960
    Location:164 → 257
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4266882..4274784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052596.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4226347..4234254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004768.1: Suppressed sequence

    Description
    NM_001004768.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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