BMP15 bone morphogenetic protein 15 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: BMP15provided by VGNC
Official Full Name: bone morphogenetic protein 15provided by VGNC
Primary source: VGNC:VGNC:85840
See related: Ensembl:ENSSSCG00000012310
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: GDF9B
Expression: Restricted expression toward ovary (RPKM 52.1) See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	X	NC_010461.5 (44613122..44620575)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	X	NC_010461.4 (49544707..49550877)

Chromosome X - NC_010461.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular characterization of the follicular development of BMP15-edited pigs.
Title: Molecular characterization of the follicular development of BMP15-edited pigs.
Efficient generation of bone morphogenetic protein 15-edited Yorkshire pigs using CRISPR/Cas9dagger.
Title: Efficient generation of bone morphogenetic protein 15-edited Yorkshire pigs using CRISPR/Cas9†.
These results show that GDF9 and BMP15 participate in cumulus expansion and that they stimulate MPF and MAPK activities in porcine oocytes during in vitro maturation.
Title: Effects of growth differentiation factor 9 and bone morphogenetic protein 15 on the in vitro maturation of porcine oocytes.
Report temporal regulation of BMP15 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
Title: Temporal regulation of BMP2, BMP6, BMP15, GDF9, BMPR1A, BMPR1B, BMPR2 and TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
BMP15mRNA and its encoded protein were expressed at low levels in immature oocytes and increased to the highest level at 18 h of IVM, which coincides with the time of cumulus cell expansion
Title: Differential gene expression of bone morphogenetic protein 15 and growth differentiation factor 9 during in vitro maturation of porcine oocytes and early embryos.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: bone morphogenetic protein 15

Names: growth differentiation factor 9B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.