rib ribbon [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ribprovided by FlyBase
Official Full Name: ribbonprovided by FlyBase
Primary source: FLYBASE:FBgn0003254
Locus tag: Dmel_CG7230
See related: AllianceGenome:FB:FBgn0003254
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7230; Dmel\CG7230; fus1; gene 5; Rib; RIB
Summary: Predicted to enable DNA-binding transcription factor activity. Involved in several processes, including embryonic morphogenesis; establishment or maintenance of epithelial cell apical/basal polarity; and open tracheal system development. Located in nucleus. Is expressed in several structures, including dorsal ectoderm; dorsal epidermis primordium; embryonic/larval midgut primordium; epidermis; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 56C6-56C6; 2-88 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19270078..19281396)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (15157583..15168901)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ribbon boosts ribosomal protein gene expression to coordinate organ form and function.
Title: Ribbon boosts ribosomal protein gene expression to coordinate organ form and function.
Rib regulates cell growth and tissue shape in the Drosophila salivary gland.
Title: Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression.
These findings suggest that Ribbon and Lola Like function as a novel transcriptional cassette coordinating molecular changes at the apical membrane of epithelial cells to facilitate tube elongation.
Title: Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	TAS Traceable Author Statement more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	NAS Non-traceable Author Statement more info	PubMed
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane organization	TAS Traceable Author Statement more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	NAS Non-traceable Author Statement more info	PubMed
involved_in open tracheal system development	TAS Traceable Author Statement more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of Malpighian tubule diameter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in salivary gland development	TAS Traceable Author Statement more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal outgrowth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: ribbon

Names: CG7230-PA; CG7230-PB; CG7230-PC; SGP cluster fusion defects 1; rib-PA; rib-PB; rib-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

19270078..19281396

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274155.1 → NP_001261084.1 ribbon, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261084.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KF43

Conserved Domains (3) summary

smart00225
Location:44 → 133

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:33 → 133

BTB; BTB/POZ domain

pfam05225
Location:373 → 417

HTH_psq; helix-turn-helix, Psq domain
NM_080534.4 → NP_536795.1 ribbon, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_536795.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KF43

Related

FBpp0085700

Conserved Domains (3) summary

smart00225
Location:44 → 133

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:33 → 133

BTB; BTB/POZ domain

pfam05225
Location:373 → 417

HTH_psq; helix-turn-helix, Psq domain
NM_001274156.2 → NP_001261085.1 ribbon, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261085.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFC4

Conserved Domains (3) summary

smart00225
Location:44 → 133

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:33 → 133

BTB; BTB/POZ domain

pfam05225
Location:373 → 417

HTH_psq; helix-turn-helix, Psq domain