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kto kohtalo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44830, updated on 2-Nov-2024

Summary

Official Symbol
ktoprovided by FlyBase
Official Full Name
kohtaloprovided by FlyBase
Primary source
FLYBASE:FBgn0001324
Locus tag
Dmel_CG8491
See related
AllianceGenome:FB:FBgn0001324
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Brm @ Kto; CG8491; Dmel\CG8491; dTrap230; dTRAP230; Kto; KTO; Kto/Med12; l(3)76BDc; med12; Med12; MED12; med12/kto; psg14; siren1; SRB8; Srb8/KTO/TRAP230; Trap230
Summary
Enables transcription coregulator activity. Involved in several processes, including autophagic cell death; positive regulation of canonical Wnt signaling pathway; and sex comb development. Located in polytene chromosome. Part of CKM complex; core mediator complex; and mediator complex. Is expressed in embryonic/larval salivary gland; organism; and spermatozoon. Used to study obesity. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to human MED12 (mediator complex subunit 12) and MED12L (mediator complex subunit 12L). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See kto in Genome Data Viewer
Location:
76D1-76D1; 3-46 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19836614..19844944)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19829714..19838044)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene tricornered Neighboring gene uncharacterized protein Neighboring gene PAPS synthetase Neighboring gene long non-coding RNA:CR45433

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of CKM complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
 
part_of mediator complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kohtalo
Names
CG8491-PA
CG8491-PB
khotalo
kto-PA
kto-PB
mediator complex subunit 12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19836614..19844944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080047.2NP_524786.1  kohtalo, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524786.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MQW4, Q9GPH4, Q9VW47
    Related
    FBpp0074653, FBtr0074884
    Conserved Domains (2) summary
    pfam09497
    Location:99157
    Med12; Transcription mediator complex subunit Med12
    pfam12145
    Location:390856
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  2. NM_001259906.1NP_001246835.1  kohtalo, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246835.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0PUX8, M9NDW3