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nmrk2 nicotinamide riboside kinase 2 [ Danio rerio (zebrafish) ]

Gene ID: 447879, updated on 2-Nov-2024

Summary

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Official Symbol
nmrk2provided by ZNC
Official Full Name
nicotinamide riboside kinase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040912-44
See related
Ensembl:ENSDARG00000067848 AllianceGenome:ZFIN:ZDB-GENE-040912-44
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
itgb1bp3; zgc:103408
Summary
Predicted to enable ribosylnicotinamide kinase activity. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Orthologous to human NMRK2 (nicotinamide riboside kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See nmrk2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (55982946..55990661)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (55859101..55866816)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488289 Neighboring gene complexin 4c Neighboring gene ATCAY kinesin light chain interacting caytaxin b Neighboring gene uncharacterized LOC137488294 Neighboring gene uncharacterized LOC108180184 Neighboring gene lysyl oxidase-like 5b Neighboring gene uncharacterized LOC137488302

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Anxiety-related behavior and associated brain transcriptome and epigenome alterations in adult female zebrafish exposed to atrazine during embryogenesis. Horzmann KA, et al. Chemosphere, 2022 Dec. PMID 36126741
  2. Nitrate-induced improvements in exercise performance are coincident with exuberant changes in metabolic genes and the metabolome in zebrafish (Danio rerio) skeletal muscle. Keller RM, et al. J Appl Physiol (1985), 2021 Jul 1. PMID 34043471, Free PMC Article
  3. Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts. Sullivan C, et al. PLoS One, 2017. PMID 28658311, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosylnicotinamide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nicotinamide riboside kinase 2
Names
integrin beta 1 binding protein 3
NP_001004618.2
NP_001314713.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004618.2 → NP_001004618.2  nicotinamide riboside kinase 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    CU013534
    UniProtKB/TrEMBL
    A0A8M1N287, F1QSP0
    Related
    ENSDARP00000088522.4, ENSDART00000097751.5

  2. NM_001327784.1 → NP_001314713.1  nicotinamide riboside kinase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CU013534, EH432193, EH485974, EH594583
    UniProtKB/TrEMBL
    A0A8M1P907, F1QSN9
    Related
    ENSDARP00000088524.4, ENSDART00000097753.6
    Conserved Domains (1) summary
    cd02024
    Location:4 → 167
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    55982946..55990661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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