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miple2 midkine and pleiotrophin 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44787, updated on 28-Oct-2024

Summary

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Official Symbol
miple2provided by FlyBase
Official Full Name
midkine and pleiotrophin 2provided by FlyBase
Primary source
FLYBASE:FBgn0029002
Locus tag
Dmel_CG18321
See related
AllianceGenome:FB:FBgn0029002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18321; Dmel\CG18321; Miple2
Summary
Enables heparin binding activity. Involved in determination of adult lifespan. Located in extracellular region. Is expressed in several structures, including embryonic/larval midgut primordium; germ layer; gut section; imaginal disc; and visceral muscle primordium. [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See miple2 in Genome Data Viewer
Location:
61B3-61B3; 3-1 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (271200..275018)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (271200..275018)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L17 Neighboring gene uncharacterized protein Neighboring gene midkine and pleiotrophin 1 Neighboring gene uncharacterized protein Neighboring gene tiny tim 2 Neighboring gene Rho guanine nucleotide exchange factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Midkine and pleiotrophin have bactericidal properties: preserved antibacterial activity in a family of heparin-binding growth factors during evolution. Svensson SL, et al. J Biol Chem, 2010 May 21. PMID 20308059, Free PMC Article
  2. The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation. Hugosson F, et al. PLoS One, 2014. PMID 25380037, Free PMC Article
  3. Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus. González-Castillo C, et al. Front Cell Neurosci, 2014. PMID 25620911, Free PMC Article
  4. Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster. Englund C, et al. Dev Genes Evol, 2006 Jan. PMID 16220264
  5. Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm. Wolfstetter G, et al. Mech Dev, 2009 Aug-Sep. PMID 19463947

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data suggest that Alk is not activated by MDK/PTN related growth factors Miple1 and Miple2 in vivo.
    Title: The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation.
  2. Strongly expressed in the developing midgut endoderm.
    Title: Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesoderm morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
midkine and pleiotrophin 2
Names
CG18321-PA
CG18321-PD
CG18321-PE
CG18321-PF
CG18321-PG
Miple2
miple2-PA
miple2-PD
miple2-PE
miple2-PF
miple2-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    271200..275018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274272.1 → NP_001261201.1  midkine and pleiotrophin 2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261201.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3W4, Q9W0S4
    Conserved Domains (1) summary
    pfam01091
    Location:156 → 201
    PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain

  2. NM_001274269.1 → NP_001261198.1  midkine and pleiotrophin 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261198.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDI0, Q9U3W4
    Conserved Domains (1) summary
    pfam01091
    Location:156 → 201
    PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain

  3. NM_001274270.1 → NP_001261199.1  midkine and pleiotrophin 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261199.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PE21, Q9U3W4
    Conserved Domains (1) summary
    pfam01091
    Location:156 → 201
    PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain

  4. NM_143739.3 → NP_651996.2  midkine and pleiotrophin 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651996.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3W4, Q9W0S4
    Related
    FBpp0072406
    Conserved Domains (1) summary
    pfam01091
    Location:156 → 201
    PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain

  5. NM_001274271.1 → NP_001261200.1  midkine and pleiotrophin 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261200.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3W4, Q9W0S4
    Conserved Domains (1) summary
    pfam01091
    Location:156 → 201
    PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDI0 M9PDI0
M9PE21 M9PE21
Q8SZ83 Q8SZ83
Q9U3W4 Q9U3W4
Q9W0S4 Q9W0S4

Gene LinkOut

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