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mta1.S metastasis associated 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 447758, updated on 4-Nov-2024

Summary

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Official Symbol
mta1.S
Official Full Name
metastasis associated 1 S homeolog
Primary source
Xenbase:XB-GENE-1188342
Locus tag
XELAEV_18002696mg
See related
EnsemblRapid:ENSXLAG00005007644 AllianceGenome:Xenbase:XB-GENE-1188342
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
mta1
Summary
Predicted to enable several functions, including chromatin binding activity; histone deacetylase binding activity; and transcription coregulator activity. Predicted to act upstream of or within double-strand break repair; negative regulation of transcription by RNA polymerase II; and response to ionizing radiation. Predicted to be located in nucleoplasm. Predicted to be part of NuRD complex. Orthologous to human MTA1 (metastasis associated 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mta1.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
23
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (90142462..90213840, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694825.1 (1749337..1788235, complement)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene RTF1 homolog, Paf1/RNA polymerase II complex component S homeolog Neighboring gene phosphofurin acidic cluster sorting protein 2 S homeolog Neighboring gene cysteine-rich protein 2 S homeolog Neighboring gene cysteine-rich protein 1 (intestinal) S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of metastasis-associated gene/protein 1 (MTA1). Toh Y, et al. Cancer Metastasis Rev, 2014 Dec. PMID 25315816
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC83916

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NuRD complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
metastasis associated 1 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094428.1 → NP_001087897.1  metastasis associated 1 S homeolog

    See identical proteins and their annotated locations for NP_001087897.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082445
    UniProtKB/TrEMBL
    Q640Z4
    Related
    ENSXLAP00005021945.1, ENSXLAT00005022636.1
    Conserved Domains (6) summary
    smart00717
    Location:269 → 316
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:270 → 315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:373 → 424
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:375 → 431
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:3 → 171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150 → 202
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    90142462..90213840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041574272.1 → XP_041430206.1  metastasis associated 1 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1LLV2
    Related
    ENSXLAP00005022047.1, ENSXLAT00005022738.1
    Conserved Domains (3) summary
    cd11661
    Location:270 → 315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:373 → 424
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3 → 171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

  2. XM_041574275.1 → XP_041430209.1  metastasis associated 1 S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1LM43
    Conserved Domains (3) summary
    cd11661
    Location:215 → 260
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:318 → 369
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cl02608
    Location:22 → 116
    BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

  3. XM_041574276.1 → XP_041430210.1  metastasis associated 1 S homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1LND7
    Related
    ENSXLAP00005022064.1, ENSXLAT00005022755.1
    Conserved Domains (3) summary
    cd11661
    Location:270 → 315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:373 → 424
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3 → 171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

  4. XM_041574277.1 → XP_041430211.1  metastasis associated 1 S homeolog isoform X4

    UniProtKB/TrEMBL
    A0A8J1LLV7
    Related
    ENSXLAP00005022085.1, ENSXLAT00005022776.1
    Conserved Domains (3) summary
    cd11661
    Location:270 → 315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:373 → 424
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3 → 171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
Nucleotide Protein Strain
Heading Accession and Version

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