nedd1.L NEDD1 gamma-tubulin ring complex targeting factor L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: nedd1.L
Official Full Name: NEDD1 gamma-tubulin ring complex targeting factor L homeolog
Primary source: Xenbase:XB-GENE-6253403
Locus tag: XELAEV_18017414mg
See related: EnsemblRapid:ENSXLAG00005006767 AllianceGenome:Xenbase:XB-GENE-6253403
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: nedd1
Summary: Predicted to enable gamma-tubulin binding activity. Predicted to act upstream of or within microtubule nucleation and mitotic cell cycle. Predicted to be located in microtubule cytoskeleton. Orthologous to human NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3L

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (58048215..58082960)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (43585960..43620846)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study identifies TPX2 as the only direct RanGTP target and NEDD1 as the only Aurora A substrate essential for the activation of the RanGTP-dependent microtubule nucleation pathway.
Title: Microtubule nucleation in mitosis by a RanGTP-dependent protein complex.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables gamma-tubulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within microtubule nucleation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in pericentriolar material	IEA Inferred from Electronic Annotation more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NEDD1 gamma-tubulin ring complex targeting factor L homeolog

Names: neural precursor cell expressed, developmentally down-regulated 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001094388.1 → NP_001087857.2 NEDD1 gamma-tubulin ring complex targeting factor L homeolog

Status: PROVISIONAL

Source sequence(s)

BC082383

UniProtKB/TrEMBL

A0A8J0Q0Y8, A0A974DDB5

Related

ENSXLAP00005020054.1, ENSXLAT00005020480.1

Conserved Domains (2) summary

cd00200
Location:50 → 315

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:97 → 133

7WD40; WD40 repeat [structural motif]