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pik3r3.L phosphoinositide-3-kinase regulatory subunit 3 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 447594, updated on 4-Nov-2024

Summary

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Official Symbol
pik3r3.L
Official Full Name
phosphoinositide-3-kinase regulatory subunit 3 L homeolog
Primary source
Xenbase:XB-GENE-6253745
Locus tag
XELAEV_18023116mg
See related
EnsemblRapid:ENSXLAG00005034265 AllianceGenome:Xenbase:XB-GENE-6253745
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
p55; pik3r3; p55-gamma
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to act upstream of or within insulin receptor signaling pathway and phosphatidylinositol phosphate biosynthetic process. Predicted to be part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pik3r3.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (87484702..87506327, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (82187996..82201941, complement)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene IZUMO1 receptor, JUNO L homeolog Neighboring gene microtubule associated serine/threonine kinase 2 L homeolog Neighboring gene uncharacterized LOC121403050 Neighboring gene uncharacterized LOC121403051

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC84470

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoinositide-3-kinase regulatory subunit 3 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094301.1 → NP_001087770.1  phosphoinositide-3-kinase regulatory subunit 3 L homeolog

    See identical proteins and their annotated locations for NP_001087770.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081193
    UniProtKB/TrEMBL
    A0A974D5F6, Q66IU1
    Related
    ENSXLAP00005102397.1, ENSXLAT00005104392.1
    Conserved Domains (4) summary
    cd09930
    Location:351 → 454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:57 → 167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    pfam16454
    Location:171 → 330
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
    cl23765
    Location:172 → 332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    87484702..87506327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018256835.2 → XP_018112324.1  phosphoinositide-3-kinase regulatory subunit 3 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UZB9
    Related
    ENSXLAP00005102506.1, ENSXLAT00005104500.1
Nucleotide Protein Strain
Heading Accession and Version

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