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pdp1.L pyruvate dehydrogenase phosphatase catalytic subunit 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 447514, updated on 4-Nov-2024

Summary

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Official Symbol
pdp1.L
Official Full Name
pyruvate dehydrogenase phosphatase catalytic subunit 1 L homeolog
Primary source
Xenbase:XB-GENE-6253767
See related
EnsemblRapid:ENSXLAG00005032374 AllianceGenome:Xenbase:XB-GENE-6253767
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
pdp1; ppm2c
Summary
Predicted to enable [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity and metal ion binding activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in obesity and pyruvate decarboxylase deficiency. Orthologous to human PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See pdp1.L in Genome Data Viewer
Location:
chromosome: 6L
Exon count:
6
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (137696414..137705875, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (128527784..128568939, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016758690.1 (1..315, complement)

Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene RNA-binding protein 12B Neighboring gene RNA binding motif protein 12B-like Neighboring gene pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial Neighboring gene RNA-binding protein 12B-like Neighboring gene traf2 and NCK-interacting protein kinase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC82628

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyruvate dehydrogenase phosphatase catalytic subunit 1 L homeolog
Names
pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog
NP_001087690.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094221.1 → NP_001087690.1  pyruvate dehydrogenase phosphatase catalytic subunit 1 L homeolog

    See identical proteins and their annotated locations for NP_001087690.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081088
    UniProtKB/TrEMBL
    Q66J23
    Related
    ENSXLAP00005097005.1, ENSXLAT00005098787.1
    Conserved Domains (1) summary
    cd00143
    Location:102 → 515
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    137696414..137705875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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