ring1.S ring finger protein 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ring1.S
Official Full Name: ring finger protein 1 S homeolog
Primary source: Xenbase:XB-GENE-6253865
Locus tag: XELAEV_18042416mg
See related: EnsemblRapid:ENSXLAG00005010449 AllianceGenome:Xenbase:XB-GENE-6253865
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: bap1; ding; rnf1; bap-1; hipi3; ring2; ring1a; ring1b; rnf2-a; ring1-a; ring1-b
Summary: Predicted to enable histone H2AK119 ubiquitin ligase activity. Predicted to act upstream of or within epigenetic regulation of gene expression and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromosome. Predicted to be part of MLL1 complex and PRC1 complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RING1 (ring finger protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 8S

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8S	NC_054386.1 (80490360..80510543)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8S	NC_030739.1 (78109114..78129415)

Chromosome 8S - NC_054386.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone H2AK119 ubiquitin ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within epigenetic regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of MLL1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of PRC1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of PcG protein complex	IEA Inferred from Electronic Annotation more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RING2-A

Names: RING finger protein 1B-A; RING finger protein 2-A; RING-type E3 ubiquitin transferase RING2-A; RING1b-A; ring finger protein 2

NP_001087647.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001094178.1 → NP_001087647.1 E3 ubiquitin-protein ligase RING2-A

See identical proteins and their annotated locations for NP_001087647.1

Status: PROVISIONAL

Source sequence(s)

BC081039

UniProtKB/Swiss-Prot

Q66J69, Q7ZWM8

Related

ENSXLAP00005030812.1, ENSXLAT00005031577.1

Conserved Domains (2) summary

pfam00097
Location:48 → 87

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam16207
Location:250 → 338

RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like