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cdk8.S cyclin-dependent kinase 8 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 447409, updated on 4-Nov-2024

Summary

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Official Symbol
cdk8.S
Official Full Name
cyclin-dependent kinase 8 S homeolog
Primary source
Xenbase:XB-GENE-962272
Locus tag
XELAEV_18016217mg
See related
EnsemblRapid:ENSXLAG00005022669 AllianceGenome:Xenbase:XB-GENE-962272
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
cdk8
Summary
Predicted to enable protein kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cdk8.S in Genome Data Viewer
Location:
chromosome: 2S
Exon count:
13
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (147916509..147992595, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (138923262..138999606, complement)

Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 12 S homeolog Neighboring gene WAS protein family member 3 S homeolog Neighboring gene shisa family member 2 S homeolog Neighboring gene nucleoporin 58kDa S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nishiyama A, et al. Nat Commun, 2020 Mar 6. PMID 32144273, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC81962

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 8
Names
cell division protein kinase 8
mediator complex subunit cdk8
mediator of RNA polymerase II transcription subunit cdk8
NP_001087585.1
XP_018103842.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094116.1 → NP_001087585.1  cyclin-dependent kinase 8

    See identical proteins and their annotated locations for NP_001087585.1

    Status: PROVISIONAL

    Source sequence(s)
    BC080386
    UniProtKB/Swiss-Prot
    Q66KH9
    UniProtKB/TrEMBL
    A0A974DRX6, A0A974HX60
    Related
    ENSXLAP00005066800.1, ENSXLAT00005068328.1
    Conserved Domains (2) summary
    smart00220
    Location:22 → 287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:3 → 287
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    147916509..147992595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018248353.2 → XP_018103842.1  cyclin-dependent kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A1L8HAP6, A0A974DRX6, A0A974HWN5
    Related
    ENSXLAP00005066773.1, ENSXLAT00005068300.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66KH9.1 GenPept UniProtKB/Swiss-Prot:Q66KH9

Gene LinkOut

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