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tia1.L TIA1 cytotoxic granule-associated RNA binding protein L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 447385, updated on 4-Nov-2024

Summary

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Official Symbol
tia1.L
Official Full Name
TIA1 cytotoxic granule-associated RNA binding protein L homeolog
Primary source
Xenbase:XB-GENE-1002882
Locus tag
XELAEV_18018533mg
See related
EnsemblRapid:ENSXLAG00005001063 AllianceGenome:Xenbase:XB-GENE-1002882
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
tia1; tia-1
Summary
Predicted to enable RNA binding activity. Is expressed in ectoderm; nervous system; pharyngeal arch; and visual system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tia1.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
13
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (129368011..129390556, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (113975408..113998049, complement)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene neuronal intermediate filament family member 1 L homeolog Neighboring gene chromosome 3 C2orf42 homolog L homeolog Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene prenylcysteine oxidase 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress. Wang F, et al. Sci Rep, 2018 Feb 8. PMID 29422626, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC84540

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TIA1 cytotoxic granule-associated RNA binding protein L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094092.1 → NP_001087561.1  TIA1 cytotoxic granule-associated RNA binding protein L homeolog

    See identical proteins and their annotated locations for NP_001087561.1

    Status: PROVISIONAL

    Source sequence(s)
    BC080105
    UniProtKB/TrEMBL
    A0A974DD83, Q68EU5
    Related
    ENSXLAP00005003202.1, ENSXLAT00005003264.1
    Conserved Domains (4) summary
    cd12615
    Location:8 → 81
    RRM1_TIA1; RNA recognition motif 1 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12618
    Location:105 → 184
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    TIGR01661
    Location:6 → 280
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:214 → 287
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    129368011..129390556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018251071.2 → XP_018106560.1  TIA1 cytotoxic granule-associated RNA binding protein L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J0UNR4

  2. XM_018251070.2 → XP_018106559.1  TIA1 cytotoxic granule-associated RNA binding protein L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8H1F1, A0A974DD61

  3. XM_018251072.2 → XP_018106561.1  TIA1 cytotoxic granule-associated RNA binding protein L homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J0UFW5
    Related
    ENSXLAP00005003200.1, ENSXLAT00005003262.1
Nucleotide Protein Strain
Heading Accession and Version

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