gmppb.L GDP-mannose pyrophosphorylase B L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: gmppb.L
Official Full Name: GDP-mannose pyrophosphorylase B L homeolog
Primary source: Xenbase:XB-GENE-922662
Locus tag: XELAEV_18023813mg
See related: EnsemblRapid:ENSXLAG00005027879 AllianceGenome:Xenbase:XB-GENE-922662
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: gmppb; gmppb-a; gmppb-b
Summary: Predicted to enable GTP binding activity and mannose-1-phosphate guanylyltransferase (GTP) activity. Predicted to act upstream of or within GDP-mannose biosynthetic process and protein glycosylation. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2T; congenital muscular dystrophy-dystroglycanopathy A14; muscular dystrophy-dystroglycanopathy; and muscular dystrophy-dystroglycanopathy type B14. Orthologous to human GMPPB (GDP-mannose pyrophosphorylase B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4L

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (124832410..124846341, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (119571901..119586038, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables mannose-1-phosphate guanylyltransferase (GTP) activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within GDP-mannose biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mannose-1-phosphate guanyltransferase beta-A

Names: GDP-mannose pyrophosphorylase B-A; GTP-mannose-1-phosphate guanylyltransferase beta-A

NP_001087522.1

EC 2.7.7.13

XP_018112311.1

EC 2.7.7.13

XP_018112314.1

EC 2.7.7.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001094053.1 → NP_001087522.1 mannose-1-phosphate guanyltransferase beta-A

See identical proteins and their annotated locations for NP_001087522.1

Status: PROVISIONAL

Source sequence(s)

BC080059

UniProtKB/Swiss-Prot

Q68EY9

UniProtKB/TrEMBL

A0A974D5P9

Related

ENSXLAP00005083256.1, ENSXLAT00005084894.1

Conserved Domains (3) summary

cd06425
Location:1 → 233

M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins

COG1208
Location:1 → 352

GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

cl00160
Location:255 → 334

LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

124832410..124846341 complement

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GenBank, FASTA, Sequence Viewer (Graphics)