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map4k5.S mitogen-activated protein kinase kinase kinase kinase 5 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 447339, updated on 4-Nov-2024

Summary

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Official Symbol
map4k5.S
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 5 S homeolog
Primary source
Xenbase:XB-GENE-6254006
Locus tag
XELAEV_18041242mg
See related
EnsemblRapid:ENSXLAG00005003521 AllianceGenome:Xenbase:XB-GENE-6254006
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
map4k5; map4k5.L
Summary
Predicted to enable ATP binding activity and protein kinase activity. Predicted to act upstream of or within intracellular signal transduction and protein phosphorylation. Predicted to be located in cytoplasm. Orthologous to human MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See map4k5.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
32
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (15646379..15739645)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (15557038..15681779)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene salvador family WW domain containing protein 1 S homeolog Neighboring gene atlastin GTPase 1 S homeolog Neighboring gene SOS Ras/Rho guanine nucleotide exchange factor 2 S homeolog Neighboring gene cyclin dependent kinase like 1 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC83247

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase kinase 5 S homeolog
Names
mitogen-activated protein kinase kinase kinase kinase 5 L homeolog
NP_001087515.2
XP_041430195.1
XP_041430196.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094046.1 → NP_001087515.2  mitogen-activated protein kinase kinase kinase kinase 5 S homeolog

    Status: PROVISIONAL

    Source sequence(s)
    BC080043
    UniProtKB/TrEMBL
    A0A8J0PZN9, Q68F04
    Related
    ENSXLAP00005010508.1, ENSXLAT00005010674.1
    Conserved Domains (3) summary
    smart00036
    Location:495 → 809
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:22 → 279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06646
    Location:12 → 279
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    15646379..15739645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041574261.1 → XP_041430195.1  mitogen-activated protein kinase kinase kinase kinase 5 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1LNC0, A0A974C2B9
    Related
    ENSXLAP00005010506.1, ENSXLAT00005010672.1
    Conserved Domains (2) summary
    smart00036
    Location:525 → 839
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:12 → 279
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

  2. XM_041574262.1 → XP_041430196.1  mitogen-activated protein kinase kinase kinase kinase 5 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1LNC0, A0A974C2B9
    Conserved Domains (2) summary
    smart00036
    Location:525 → 839
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:12 → 279
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
Nucleotide Protein Strain
Heading Accession and Version

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