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sucla2.S succinate-CoA ligase, ADP-forming, beta subunit S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 447333, updated on 4-Nov-2024

Summary

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Official Symbol
sucla2.S
Official Full Name
succinate-CoA ligase, ADP-forming, beta subunit S homeolog
Primary source
Xenbase:XB-GENE-952592
Locus tag
XELAEV_18015790mg
See related
EnsemblRapid:ENSXLAG00005035369 AllianceGenome:Xenbase:XB-GENE-952592
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
sucla2
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and succinate-CoA ligase (ADP-forming) activity. Predicted to act upstream of or within succinyl-CoA metabolic process and tricarboxylic acid cycle. Predicted to be located in mitochondrion. Predicted to be part of succinate-CoA ligase complex. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 5. Orthologous to human SUCLA2 (succinate-CoA ligase ADP-forming subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sucla2.S in Genome Data Viewer
Location:
chromosome: 2S
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (126391848..126417221, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (117357620..117382993, complement)

Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene esterase D S homeolog Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled S homeolog Neighboring gene mediator complex subunit 4 S homeolog Neighboring gene retinoblastoma 1 S homeolog Neighboring gene lysophosphatidic acid receptor 6 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC82958

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within succinyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of succinate-CoA ligase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
succinate-CoA ligase, ADP-forming, beta subunit S homeolog
NP_001087509.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094040.1 → NP_001087509.1  succinate-CoA ligase, ADP-forming, beta subunit S homeolog

    See identical proteins and their annotated locations for NP_001087509.1

    Status: PROVISIONAL

    Source sequence(s)
    BC080033
    UniProtKB/TrEMBL
    A0A974DJ45, Q68F13
    Related
    ENSXLAP00005106077.1, ENSXLAT00005108152.1
    Conserved Domains (3) summary
    PLN00124
    Location:41 → 441
    PLN00124; succinyl-CoA ligase [GDP-forming] subunit beta; Provisional
    pfam00549
    Location:316 → 436
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:50 → 257
    ATP-grasp_2; ATP-grasp domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    126391848..126417221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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