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dpyd.L dihydropyrimidine dehydrogenase L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 447312, updated on 4-Nov-2024

Summary

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Official Symbol
dpyd.L
Official Full Name
dihydropyrimidine dehydrogenase L homeolog
Primary source
Xenbase:XB-GENE-6078545
Locus tag
XELAEV_18023304mg
See related
EnsemblRapid:ENSXLAG00005032015 AllianceGenome:Xenbase:XB-GENE-6078545
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
dhp; dpd; dpyd; dhpdhase
Summary
Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dpyd.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
23
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (98256125..98660508, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (92987290..93392439, complement)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene RWD domain containing 3 L homeolog Neighboring gene polypyrimidine tract binding protein 2 L homeolog Neighboring gene uncharacterized LOC121403069 Neighboring gene sorting nexin 7 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC81821

General protein information

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Preferred Names
dihydropyrimidine dehydrogenase L homeolog; dihydropyrimidine dehydrogenase [NADP(+)]
XP_041446463.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    98256125..98660508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041590529.1 → XP_041446463.1  dihydropyrimidine dehydrogenase [NADP(+)]

    UniProtKB/TrEMBL
    A0A1L8GMQ4, A0A974D4T0, Q68F42
    Related
    ENSXLAP00005098425.1, ENSXLAT00005100244.1
    Conserved Domains (3) summary
    cd02940
    Location:532 → 834
    DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
    pfam14697
    Location:946 → 1004
    Fer4_21; 4Fe-4S dicluster domain
    cl40752
    Location:53 → 509
    GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001094019.1: Suppressed sequence

    Description
    NM_001094019.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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