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twf1.S twinfilin actin binding protein 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 447307, updated on 4-Nov-2024

Summary

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Official Symbol
twf1.S
Official Full Name
twinfilin actin binding protein 1 S homeolog
Primary source
Xenbase:XB-GENE-865829
Locus tag
XELAEV_18021116mg
See related
EnsemblRapid:ENSXLAG00005021046 AllianceGenome:Xenbase:XB-GENE-865829
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ptk9; twf1
Summary
Predicted to enable actin filament binding activity and actin monomer binding activity. Predicted to act upstream of or within actin filament depolymerization; negative regulation of actin filament polymerization; and regulation of plasma membrane bounded cell projection organization. Predicted to be located in actin filament and myofibril. Orthologous to human TWF1 (twinfilin actin binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See twf1.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (83785833..83816664, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (82334427..82366079, complement)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121402189 Neighboring gene uncharacterized protein MGC115291 Neighboring gene transmembrane protein 117 S homeolog Neighboring gene neural EGFL like 2 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC81683

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sequestering of actin monomers IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin filament IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in myofibril IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
twinfilin-1
Names
twinfilin actin-binding protein 1
twinfilin, actin-binding protein, homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094014.1 → NP_001087483.1  twinfilin-1

    See identical proteins and their annotated locations for NP_001087483.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079994
    UniProtKB/Swiss-Prot
    Q68F50
    UniProtKB/TrEMBL
    A0A974HRN8
    Related
    ENSXLAP00005061794.1, ENSXLAT00005063247.1
    Conserved Domains (2) summary
    cd11284
    Location:176 → 311
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:4 → 142
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    83785833..83816664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68F50.1 GenPept UniProtKB/Swiss-Prot:Q68F50

Gene LinkOut

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