unc45b.S unc-45 myosin chaperone B S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: unc45b.S
Official Full Name: unc-45 myosin chaperone B S homeolog
Primary source: Xenbase:XB-GENE-971733
Locus tag: XELAEV_18015301mg
See related: EnsemblRapid:ENSXLAG00005003841 AllianceGenome:Xenbase:XB-GENE-971733
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: cmya4; unc45; unc45b; Unc-45B; smunc45
Summary: Predicted to enable Hsp90 protein binding activity. Predicted to act upstream of or within lens development in camera-type eye. Predicted to be located in cytosol; perinuclear region of cytoplasm; and sarcomere. Is expressed in cardiovascular system and musculoskeletal system. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy 11. Orthologous to human UNC45B (unc-45 myosin chaperone B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2S

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (85438090..85462948)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (76872086..76897173)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chaperone-mediated protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in A band	IEA Inferred from Electronic Annotation more info
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein unc-45 homolog B

Names: dicky ticker; unc-45 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001094003.1 → NP_001087472.1 protein unc-45 homolog B

See identical proteins and their annotated locations for NP_001087472.1

Status: PROVISIONAL

Source sequence(s)

BC079980

UniProtKB/Swiss-Prot

Q68F64

UniProtKB/TrEMBL

A0A974DJJ9

Related

ENSXLAP00005011499.1, ENSXLAT00005011673.1

Conserved Domains (6) summary

smart00028
Location:11 → 33

TPR; Tetratricopeptide repeats

cd00020
Location:713 → 829

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00006
Location:7 → 32

TPR; TPR repeat [structural motif]

pfam11701
Location:341 → 486

UNC45-central; Myosin-binding striated muscle assembly central

pfam13414
Location:3 → 71

TPR_11; TPR repeat

sd00043
Location:749 → 783

ARM; armadillo repeat [structural motif]