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san separation anxiety [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44724, updated on 2-Nov-2024

Summary

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Official Symbol
sanprovided by FlyBase
Official Full Name
separation anxietyprovided by FlyBase
Primary source
FLYBASE:FBgn0024188
Locus tag
Dmel_CG12352
See related
AllianceGenome:FB:FBgn0024188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
atado; CG12352; DmAAF34715; Dmel\CG12352; dNaa50; Naa50; NAA50; San; span
Summary
Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation; mitotic cell cycle; and mitotic sister chromatid cohesion. Located in cytosol. Part of NatA complex. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; hindgut anlage; and posterior endoderm. Orthologous to human NAA50 (N-alpha-acetyltransferase 50, NatE catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See san in Genome Data Viewer
Location:
47F5-47F5; 2-64 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11360706..11361871)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7248211..7249376)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene intersex Neighboring gene Gustatory receptor 47b Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster. Drolia R, et al. Int J Med Microbiol, 2013 Jan. PMID 23306065, Free PMC Article
  2. A glycoprotein binding retinoids and fatty acids is present in Drosophila. Duncan T, et al. Arch Biochem Biophys, 1994 Jul. PMID 8031123
  3. Developmental roles of protein N-terminal acetylation. Silva RD, et al. Proteomics, 2015 Jul. PMID 25920796
  4. Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication. Castorena KM, et al. BMC Genomics, 2010 Mar 17. PMID 20236518, Free PMC Article
  5. intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation. Garrett-Engele CM, et al. Development, 2002 Oct. PMID 12361959

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that during tissue proliferation San behaves as general regulator of sister chromatid cohesion, as it facilitates the correct interaction between cohesin subunits Scc1/Rad21/Vtd and Smc3. Also, the results suggest a working model where Naa50/San N-terminally acetylates the nascent Scc1 polypeptide, which is subsequently required for the correct establishment and maintenance of sister chromatid cohesion.
    Title: Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion.
  2. san is required in vivo for normal mitosis of different types of somatic cells.
    Title: Differential requirements of a mitotic acetyltransferase in somatic and germ line cells.
  3. plays vital roles in regulating sister chromatid cohesion during Drosophila mitosis
    Title: Two putative acetyltransferases, san and deco, are required for establishing sister chromatid cohesion in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N-acetyltransferase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables N-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables peptide alpha-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-terminal protein amino acid acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NatA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
separation anxiety
Names
CG12352-PA
N(alpha)-acetyltransferase 50
atado
complementation group 2
san-PA
NP_524779.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11360706..11361871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080040.5 → NP_524779.1  separation anxiety [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524779.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NHD5
    Related
    FBpp0087227
    Conserved Domains (2) summary
    COG0456
    Location:27 → 145
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:50 → 130
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NHD5.1 Q9NHD5

Gene LinkOut

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