hspb1.L heat shock protein family B (small) member 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hspb1.L
Official Full Name: heat shock protein family B (small) member 1 L homeolog
Primary source: Xenbase:XB-GENE-865364
Locus tag: XELAEV_18012694mg
See related: AllianceGenome:Xenbase:XB-GENE-865364
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: hsp27; hspb1
Summary: Predicted to enable metal ion binding activity and unfolded protein binding activity. Predicted to act upstream of or within negative regulation of apoptotic process; protein refolding; and response to heat. Predicted to be located in cytoplasm; nucleus; and spindle. Is expressed in cardiovascular system; musculoskeletal system; and nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; autosomal dominant distal hereditary motor neuronopathy 3; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 2L

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (98121715..98133083)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (92384775..92396293)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
Title: The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
Xenopus HSP27, like HSP30, is a developmentally-regulated heat-inducible molecular chaperone.
Title: Analysis of the expression and function of the small heat shock protein gene, hsp27, in Xenopus laevis embryos.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein refolding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to heat	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heat shock protein family B (small) member 1 L homeolog

Names: heat shock 27kDa protein 1; heat shock protein 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093816.1 → NP_001087285.1 heat shock protein family B (small) member 1 L homeolog

See identical proteins and their annotated locations for NP_001087285.1

Status: PROVISIONAL

Source sequence(s)

DQ473544

UniProtKB/TrEMBL

Q66KY8

Conserved Domains (2) summary

cd06475
Location:92 → 177

ACD_HspB1_like; Alpha crystallin domain (ACD) found in mammalian small (s)heat shock protein (Hsp)-27 (also denoted HspB1 in human) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally ...

COG0071
Location:95 → 191

IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]