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prkca.L protein kinase C, alpha L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 447031, updated on 18-Sep-2024

Summary

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Official Symbol
prkca.L
Official Full Name
protein kinase C, alpha L homeolog
Primary source
Xenbase:XB-GENE-5942910
Locus tag
XELAEV_18044251mg
See related
EnsemblRapid:ENSXLAG00005016243
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
XPKCI; prkca; prkca.S; pkcalpha; pkc-alpha
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Genomic context

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See prkca.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
19
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (53898896..54011403)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (43345270..43457047)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 112kDa L homeolog Neighboring gene apolipoprotein H L homeolog Neighboring gene calcium channel, voltage-dependent, gamma subunit 5 L homeolog Neighboring gene calcium channel, voltage-dependent, gamma subunit 4 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors. Matavel A, et al. J Mol Cell Cardiol, 2009 May. PMID 19233191, Free PMC Article
  2. aPKC phosphorylates p27Xic1, providing a mechanistic link between apicobasal polarity and cell-cycle control. Sabherwal N, et al. Dev Cell, 2014 Dec 8. PMID 25490266, Free PMC Article
  3. Closed-state inactivation in Kv4.3 isoforms is differentially modulated by protein kinase C. Xie C, et al. Am J Physiol Cell Physiol, 2009 Nov. PMID 19675305, Free PMC Article
  4. A role for Syndecan-4 in neural induction involving ERK- and PKC-dependent pathways. Kuriyama S, et al. Development, 2009 Feb. PMID 19144724, Free PMC Article
  5. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2, leading to shortening of G1 and S phases
    Title: aPKC phosphorylates p27Xic1, providing a mechanistic link between apicobasal polarity and cell-cycle control.
  2. Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C in Kv4.3
    Title: Closed-state inactivation in Kv4.3 isoforms is differentially modulated by protein kinase C.
  3. The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC of the KCNE1 subunit underlies the GqPCR-mediated channel activation.
    Title: PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors.
  4. Neural induction by Syn4 through the PKC pathway requires inhibition of PKCdelta and activation of PKCalpha.
    Title: A role for Syndecan-4 in neural induction involving ERK- and PKC-dependent pathways.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC82897

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
protein kinase C, alpha L homeolog
Names
pkc-like 2
protein kinase C, alpha S homeolog
NP_001087142.1
XP_041431603.1
XP_041431604.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093673.1 → NP_001087142.1  protein kinase C, alpha L homeolog

    See identical proteins and their annotated locations for NP_001087142.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078065
    UniProtKB/TrEMBL
    A0A974H327, Q6AZF7, Q7LZQ9
    Related
    ENSXLAP00005047802.1, ENSXLAT00005048917.1
    Conserved Domains (4) summary
    cd04026
    Location:163 → 293
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:344 → 602
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05615
    Location:333 → 673
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    pfam00130
    Location:41 → 93
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    53898896..54011403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041575670.1 → XP_041431604.1  protein kinase C, alpha L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1LQS3, Q7LZQ9
    Conserved Domains (2) summary
    cd04026
    Location:30 → 160
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:208 → 548
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha

  2. XM_041575669.1 → XP_041431603.1  protein kinase C, alpha L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1LPV0, Q7LZQ9
    Related
    ENSXLAP00005047812.1, ENSXLAT00005048927.1
    Conserved Domains (3) summary
    cd04026
    Location:163 → 293
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00109
    Location:41 → 90
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd05615
    Location:341 → 681
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
Nucleotide Protein Strain
Heading Accession and Version

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