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manba.L mannosidase, beta A, lysosomal L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 447024, updated on 4-Nov-2024

Summary

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Official Symbol
manba.L
Official Full Name
mannosidase, beta A, lysosomal L homeolog
Primary source
Xenbase:XB-GENE-985701
Locus tag
XELAEV_18005720mg
See related
EnsemblRapid:ENSXLAG00005009245 AllianceGenome:Xenbase:XB-GENE-985701
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
manba
Summary
Predicted to enable beta-mannosidase activity. Predicted to act upstream of or within carbohydrate metabolic process and glycoprotein catabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See manba.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
17
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (78057860..78082195)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (67199756..67224467)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene CDGSH iron sulfur domain 2 L homeolog Neighboring gene ubiquitin conjugating enzyme E2 D3 L homeolog Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 L homeolog Neighboring gene solute carrier family 39 (zinc transporter), member 8 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC82825

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables beta-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycoprotein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mannosidase, beta A, lysosomal L homeolog
NP_001087135.1
XP_018102608.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093666.1 → NP_001087135.1  mannosidase, beta A, lysosomal L homeolog

    See identical proteins and their annotated locations for NP_001087135.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078052
    UniProtKB/TrEMBL
    A0A974DZS8, Q6DCI1
    Related
    ENSXLAP00005026943.1, ENSXLAT00005027675.1
    Conserved Domains (3) summary
    COG3250
    Location:21 → 737
    LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]
    pfam00703
    Location:210 → 320
    Glyco_hydro_2; Glycosyl hydrolases family 2
    cl23725
    Location:395 → 572
    Glyco_hydro_1; Glycosyl hydrolase family 1

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    78057860..78082195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018247119.2 → XP_018102608.1  mannosidase, beta A, lysosomal L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0U7Q3, A0A974DZS8
    Related
    ENSXLAP00005026967.1, ENSXLAT00005027699.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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