selenos.L selenoprotein S L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: selenos.L
Official Full Name: selenoprotein S L homeolog
Primary source: Xenbase:XB-GENE-6254582
Locus tag: XELAEV_18018417mg
See related: AllianceGenome:Xenbase:XB-GENE-6254582
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: vimp; ADO15; SBBI8; seps1; AD-015; sels-a; vimp-a; vimp.L
Summary: This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional stem-loop structures in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. A homeolog of this gene is found on chromosome 3S. [provided by RefSeq, Jul 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3L

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (122356068..122363331, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (106942935..106950113, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retrograde protein transport, ER to cytosol	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Derlin-1 retrotranslocation complex	IEA Inferred from Electronic Annotation more info
part_of Derlin-1-VIMP complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: selenoprotein S L homeolog

Names: VCP-interacting membrane protein; VCP-interacting membrane selenoprotein L homeolog; selS A; selenoprotein S A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093656.2 → NP_001087125.2 selenoprotein S L homeolog

Status: REVIEWED

Source sequence(s)

BC078025, BG038772, DT058072

UniProtKB/Swiss-Prot

Q6AZH0

UniProtKB/TrEMBL

A0A974DD46

Conserved Domains (1) summary

pfam06936
Location:1 → 191

Selenoprotein_S; Selenoprotein S (SelS)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

122356068..122363331 complement

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GenBank, FASTA, Sequence Viewer (Graphics)