rasgrp2.L RAS guanyl releasing protein 2 (calcium and DAG-regulated) L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: rasgrp2.L
Official Full Name: RAS guanyl releasing protein 2 (calcium and DAG-regulated) L homeolog
Primary source: Xenbase:XB-GENE-986629
Locus tag: XELAEV_18022350mg
See related: EnsemblRapid:ENSXLAG00005008154 AllianceGenome:Xenbase:XB-GENE-986629
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rasgrp2; xrasgrp2; rasgrp2-a; rasgrp2-b; rasgrp2.S
Summary: Predicted to enable calcium ion binding activity and guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within Ras protein signal transduction and positive regulation of GTPase activity. Predicted to be located in several cellular components, including cytosol; neuron projection; and synapse. Is expressed in cardiovascular system; nervous system; and visual system. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 18. Orthologous to human RASGRP2 (RAS guanyl releasing protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4L

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (31836595..31902325)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (30044914..30071917)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rasgrp2 is essential for blood vessel formation during Xenopus development.
Title: XRASGRP2 is essential for blood vessel formation during Xenopus development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RAS guanyl-releasing protein 2-B

Names: RAS guanyl releasing protein 2 (calcium and DAG-regulated) S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093650.1 → NP_001087119.1 RAS guanyl-releasing protein 2-B

See identical proteins and their annotated locations for NP_001087119.1

Status: PROVISIONAL

Source sequence(s)

BC078012

UniProtKB/Swiss-Prot

Q6DCK3

UniProtKB/TrEMBL

A0A974CYB8

Related

ENSXLAP00005023420.1, ENSXLAT00005024125.1

Conserved Domains (5) summary

cd06224
Location:11 → 122

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:145 → 382

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:491 → 540

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:422 → 472

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:423 → 476

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

31836595..31902325

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041589339.1 → XP_041445273.1 RAS guanyl-releasing protein 2-B isoform X1

UniProtKB/TrEMBL

A0A1L8GK53, A0A974CYB8, A0A974D271

Conserved Domains (4) summary

cd06224
Location:11 → 122

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:145 → 382

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00051
Location:422 → 472

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl00040
Location:488 → 543

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_041589341.1 → XP_041445275.1 RAS guanyl-releasing protein 2-B isoform X2

UniProtKB/TrEMBL

A0A8J1MW93, A0A974CYB8

Conserved Domains (3) summary

smart00109
Location:422 → 471

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00147
Location:76 → 313

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00051
Location:353 → 403

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...