tnfaip3.S TNF alpha induced protein 3 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tnfaip3.S
Official Full Name: TNF alpha induced protein 3 S homeolog
Primary source: Xenbase:XB-GENE-6254829
Locus tag: XELAEV_18029097mg
See related: EnsemblRapid:ENSXLAG00005008730 AllianceGenome:Xenbase:XB-GENE-6254829
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: a20; otud7c; tnfa1p2; tnfaip3
Summary: Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; cysteine-type deubiquitinase activity; and zinc ion binding activity. Predicted to act upstream of or within several processes, including cytoskeleton organization; positive regulation of Wnt signaling pathway; and protein deubiquitination. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (47736193..47763812, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (47532100..47559260, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016732193.1 (50..504, complement)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables K63-linked polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein K29-linked deubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein K33-linked deubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein deubiquitination involved in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TNF alpha induced protein 3 S homeolog

Names: tumor necrosis factor, alpha-induced protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093640.1 → NP_001087109.1 TNF alpha induced protein 3 S homeolog

See identical proteins and their annotated locations for NP_001087109.1

Status: PROVISIONAL

Source sequence(s)

BC077994

UniProtKB/TrEMBL

Q6DCL4

Related

ENSXLAP00005025316.1, ENSXLAT00005026026.1

Conserved Domains (2) summary

smart00259
Location:590 → 613

ZnF_A20; A20-like zinc fingers

cl19932
Location:100 → 258

OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

47736193..47763812 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041564028.1 → XP_041419962.1 TNF alpha induced protein 3 S homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8G2B0, A0A974CSR8

Conserved Domains (2) summary

smart00259
Location:590 → 613

ZnF_A20; A20-like zinc fingers

cl19932
Location:100 → 258

OTU; OTU-like cysteine protease
XM_041564029.1 → XP_041419963.1 TNF alpha induced protein 3 S homeolog isoform X2

UniProtKB/TrEMBL

A0A8J1KT89

Conserved Domains (1) summary

smart00259
Location:590 → 613

ZnF_A20; A20-like zinc fingers