capn10l.L calpain 10-like L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: capn10l.L
Official Full Name: calpain 10-like L homeolog
Primary source: Xenbase:XB-GENE-5889690
Locus tag: XELAEV_18026314mg
See related: EnsemblRapid:ENSXLAG00005034281
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: capn1; capn3; capn1.L
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Genomic context

Location:: chromosome: 5L

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (19043827..19090338)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (18360212..18407525)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our results suggest that calcium influx through mechanosensitive TRPC1 channels on filopodia activates calpain to control growth cone turning during development.
Title: Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: calpain 3

Names: calpain 1, (mu/I) large subunit L homeolog; calpain 3, (p94)

NP_001087053.1

EC 3.4.22.54

XP_018117464.1

EC 3.4.22.54

XP_018117465.1

EC 3.4.22.54

XP_018117466.1

EC 3.4.22.54

XP_041418155.1

EC 3.4.22.54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093584.1 → NP_001087053.1 calpain 3

See identical proteins and their annotated locations for NP_001087053.1

Status: PROVISIONAL

Source sequence(s)

BC077948

UniProtKB/TrEMBL

A0A974HIR1, Q6DCQ4

Related

ENSXLAP00005102526.1, ENSXLAT00005104521.1

Conserved Domains (4) summary

pfam00648
Location:39 → 361

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:396 → 513

Calpain_III; Calpain large subunit, domain III

pfam13499
Location:612 → 668

EF-hand_7; EF-hand domain pair

cl08302
Location:610 → 647

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

19043827..19090338

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041562221.1 → XP_041418155.1 calpain 3 isoform X3

UniProtKB/TrEMBL

A0A8J1KLH2

Related

ENSXLAP00005102692.1, ENSXLAT00005104687.1

Conserved Domains (3) summary

cd16195
Location:531 → 687

EFh_PEF_CAPN13_14; Penta-EF hand, calcium binding motifs, found in calpain-13 (CAPN13), calpain-14 (CAPN14), and similar proteins

cl00051
Location:25 → 372

CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

cl00165
Location:396 → 513

Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
XM_018261976.2 → XP_018117465.1 calpain 3 isoform X2

UniProtKB/TrEMBL

A0A8J0VE06
XM_018261975.2 → XP_018117464.1 calpain 3 isoform X1

UniProtKB/TrEMBL

A0A974HIR1, Q6DCQ4
XM_018261977.2 → XP_018117466.1 calpain 3 isoform X4

UniProtKB/TrEMBL

A0A8J0V971

Related

ENSXLAP00005102391.1, ENSXLAT00005104386.1