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cbfb.S core-binding factor subunit beta S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 446882, updated on 4-Nov-2024

Summary

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Official Symbol
cbfb.S
Official Full Name
core-binding factor subunit beta S homeolog
Primary source
Xenbase:XB-GENE-6078733
Locus tag
XELAEV_18024795mg
See related
EnsemblRapid:ENSXLAG00005013992 AllianceGenome:Xenbase:XB-GENE-6078733
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
cbfb; pebp2b; cbfbeta; cbf-beta; pea2-beta; pebp2-beta
Summary
Predicted to enable sequence-specific DNA binding activity and transcription coactivator activity. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core-binding activity factor complex. Is expressed in musculoskeletal system; nervous system; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human CBFB (core-binding factor subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cbfb.S in Genome Data Viewer
Location:
chromosome: 4S
Exon count:
6
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (33190629..33213438)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (32209770..32232656)

Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene autocrine motility factor receptor S homeolog Neighboring gene G protein subunit alpha o1 S homeolog Neighboring gene phagosome assembly factor 1 S homeolog Neighboring gene heat shock transcription factor 4 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC80899

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core-binding factor complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
core-binding factor subunit beta S homeolog
Names
core-binding factor, beta subunit S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093578.1 → NP_001087047.1  core-binding factor subunit beta S homeolog

    See identical proteins and their annotated locations for NP_001087047.1

    Status: PROVISIONAL

    Source sequence(s)
    BC077938
    UniProtKB/TrEMBL
    A0A974HLR7, Q6AZI5
    Related
    ENSXLAP00005041305.1, ENSXLAT00005042246.1
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 165
    CBF_beta; Core binding factor beta subunit

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    33190629..33213438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018259639.1 → XP_018115128.1  core-binding factor subunit beta S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A974HLR7, Q6AZI5
    Related
    ENSXLAP00005041314.1, ENSXLAT00005042255.1

  2. XM_018259640.1 → XP_018115129.1  core-binding factor subunit beta S homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J0V3U1

  3. XM_018259638.1 → XP_018115127.1  core-binding factor subunit beta S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8GEE9, A0A974HL95
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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