atp2b2.L ATPase plasma membrane Ca2+ transporting 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: atp2b2.L
Official Full Name: ATPase plasma membrane Ca2+ transporting 2 L homeolog
Primary source: Xenbase:XB-GENE-960661
Locus tag: XELAEV_18023767mg
See related: EnsemblRapid:ENSXLAG00005031704 AllianceGenome:Xenbase:XB-GENE-960661
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mxra1; pmca4; atp2b2; atp2b3; atp2b4; pmca4b; pmca4x; atp2b4.L; atp2b4.S
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and PDZ domain binding activity. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of cytosolic calcium ion concentration. Predicted to be located in intracellular membrane-bounded organelle and postsynaptic density membrane. Orthologous to human ATP2B4 (ATPase plasma membrane Ca2+ transporting 4). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 4L

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (122988077..123167977)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (117716653..117896638)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATPase plasma membrane Ca2+ transporting 2 L homeolog

Names: ATPase, Ca++ transporting, plasma membrane 2 L homeolog; ATPase, Ca++ transporting, plasma membrane 3; ATPase, Ca++ transporting, plasma membrane 4 L homeolog; ATPase, Ca++ transporting, plasma membrane 4 S homeolog; plasma membrane calcium ATPase 3

NP_001087020.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093551.1 → NP_001087020.1 ATPase plasma membrane Ca2+ transporting 2 L homeolog

See identical proteins and their annotated locations for NP_001087020.1

Status: PROVISIONAL

Source sequence(s)

BC077905

UniProtKB/TrEMBL

A0A974D4R1, Q6DCT8

Related

ENSXLAP00005094991.1, ENSXLAT00005096708.1

Conserved Domains (7) summary

cd01427
Location:696 → 840

HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...

TIGR01517
Location:12 → 1090

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam00122
Location:193 → 491

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:906 → 1084

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:48 → 113

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12424
Location:1129 → 1193

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

pfam13246
Location:548 → 641

Cation_ATPase; Cation transport ATPase (P-type)